ArticleInternational journal of women's health2026
Labor Induction Outcomes and Short-Term Safety of Controlled-Release Vaginal Dinoprostone in Women Beyond 36 Weeks of Gestation: A Prospective Observational Study in Vietnam.
Article in International journal of women's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: To describe labor induction outcomes and short-term maternal and neonatal adverse events following controlled-release vaginal dinoprostone use in women beyond 36 weeks of gestation at a provincial obstetric hospital in Vietnam. Methods: This prospective, single-center observational study included 102 women who received controlled-release vaginal dinoprostone during routine inpatient care at Thai Binh Obstetrics and Gynecology Hospital from January to June 2025. Eligible women had singleton, live, cephalic pregnancies beyond 36 weeks of gestation, a Bishop score ≤4, and no contraindication to vaginal delivery. The primary outcome was successful induction within 24 hours. Secondary outcomes included vaginal and cesarean delivery, time-to-event outcomes, short-term maternal and neonatal adverse events, and factors associated with induction success. No concurrent comparison group was included. Results: The mean maternal age was 28.5 ± 5.5 years, the mean gestational age was 39.8 ± 1.3 weeks, and the mean baseline Bishop score was 3.37 ± 0.82. Successful induction occurred in 84 women (82.4%; 95% CI: 73.8-88.5), and 81 women delivered vaginally (79.4%; 95% CI: 70.6-86.1). The mean interval from insertion to successful induction was 8.0 ± 5.3 hours, and the mean interval to vaginal delivery was 10.6 ± 5.8 hours. Uterine tachysystole/hyperstimulation occurred in 4 women (3.9%) and fetal distress in 3 (2.9%). No uterine rupture, postpartum hemorrhage, birth asphyxia, or 5-minute Apgar score <7 was recorded. Higher baseline Bishop score was strongly associated with successful induction (p<0.001). Conclusion: In this prospective observational cohort, high proportions of women achieved successful induction and vaginal delivery, and few short-term maternal or neonatal adverse events were recorded. Baseline Bishop score was associated with induction success. Because the study had no comparison group, the findings describe outcomes after dinoprostone use rather than comparative efficacy. Larger multicenter comparative studies are needed before the results are generalized to other populations and care settings.
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