Trial reportPeerJ2026
Effect of early regional anesthesia on postoperative cognitive function and the perioperative stress response in patients with hip fractures: a randomized controlled trial.
Trial report in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Whether early application of anterior iliopsoas muscle space block (AIMSB) impacts postoperative cognitive function remains uncertain. This study aimed to compare the incidence of postoperative delirium (POD) among patients who received AIMSB at different time points. Methods: This prospective, single-blind, randomized trial enrolled 79 patients aged ≥65 years hospitalized for primary unilateral total hip arthroplasty (THA) due to hip fractures (December 2022 to February 2024). All patients underwent spinal anesthesia. Participants were randomized to receive AIMSB either the day before surgery (D group, Results: Seventy-six patients completed the study per protocol. POD incidence was 8.1% (3/37) in the day-before-surgery group and 12.8% (5/39) in the hour-before-surgery group (risk difference, -4.7%; 95% CI [-18.4% to 9.0%]; Conclusions: Among elderly patients undergoing THA for hip fracture, performing AIMSB one day preoperatively, compared to one hour preoperatively, did not significantly reduce the incidence of POD. An exploratory analysis suggested a transient early postoperative pain benefit, that did not survive multiplicity correction. These findings warrant further investigation in larger, appropriately powered trials.
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