ReviewInternational journal of general medicine2026
Sleep Disturbances and Sarcopenia in Older Adults: Clinical Associations, Potential Mechanisms, and Management Strategies.
Review in International journal of general medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sarcopenia is an age-related syndrome characterized by reduced skeletal muscle mass, decreased muscle strength, and impaired physical performance, and is an important contributor to falls, disability, hospitalization, and mortality in older adults. Sleep disturbances, including abnormal sleep duration, poor sleep quality, insomnia, circadian disruption, and obstructive sleep apnea (OSA), are also highly prevalent in this population and may be associated with poorer physical performance. Accumulating observational evidence suggests an association between sleep disturbances and sarcopenia, although its directionality remains uncertain. This narrative review summarizes current clinical evidence linking sleep disturbances to sarcopenia in older adults, discusses potential biological and behavioral pathways underlying this relationship, and outlines clinically relevant management strategies. A particular focus is the comparison of evidence across sleep domains, sarcopenia components, and study designs, distinguishing clinically defined sarcopenia from individual muscle traits and biological plausibility from demonstrated mediation. Potential pathways involve circadian disruption, neuroendocrine and metabolic dysregulation, chronic inflammation, mitochondrial dysfunction and oxidative stress, although direct mechanistic evidence in older adults remains limited. Sleep assessment and management of clinically identified sleep disturbances may complement exercise and nutritional support, but their effects on sarcopenia outcomes remain uncertain. The available clinical evidence is predominantly observational and often cross-sectional; prospective studies and adequately powered randomized trials in older adults with both conditions are needed to clarify causality and treatment benefits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.