ArticleJournal of transplantation2026
Thoracoabdominal Normothermic Regional Perfusion Attenuates the Protective Effect of Hypothermic Machine Perfusion on Delayed Graft Function in DCD Kidney Transplantation.
Article in Journal of transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
Funding
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Abstract
Background: Thoracoabdominal normothermic regional perfusion (TA-NRP) and hypothermic machine perfusion (HMP) reduce ischemia-reperfusion injury after donation after circulatory death (DCD) kidney transplantation, but their combined effects remain unclear. Methods: Adult DCD kidney-only recipients undergoing pretransplant dialysis in the OPTN registry (2020-2025) were stratified by TA-NRP and HMP. The primary outcome was delayed graft function (DGF). Multivariable logistic regression included a TA-NRP × HMP interaction and adjusted for recipient and donor factors. Death-censored graft survival (DCGS) was evaluated by Kaplan-Meier analysis. Results: Among 3502 recipients, DGF differed by preservation strategy. In the non-TA-NRP cohort, HMP significantly reduced DGF compared with static cold storage (SCS) (44.2% vs 53.8%; Conclusion: TA-NRP was associated with lower DGF than conventional DCD procurement. Within the TA-NRP cohort, HMP was not associated with additional reductions in DGF. These findings should be interpreted in light of the surrogate definition used to identify TA-NRP in the OPTN registry and warrant prospective validation.
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