Evidence map›Paper›PMID 42829558›Full record

ReviewSurgical neurology international2026

Investigating the neurological function and anti-inflammatory effects of resveratrol in small mammal spinal cord injury models: A systematic review and meta-analysis.

Amirreza Peyrovinasab, Mahrokh Janmohamadi, Mohammadhossein Vazirizadeh-Mahabadi, Mobina Yarahmadi, Arash Sarveazad, Alexander Vaccaro, Vafa Rahimi-Movaghar, Mahmoud Yousefifard

Abstract readReview
In one paragraph

Review in Surgical neurology international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Amirreza PeyrovinasabPhysiology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Mahrokh JanmohamadiPhysiology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Mohammadhossein Vazirizadeh-MahabadiPhysiology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Mobina YarahmadiPhysiology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Arash SarveazadColorectal Research Center, Iran University of Medical Sciences, Tehran, Iran.
Alexander VaccaroDepartment of Orthopedics and Neurosurgery, Rothman Institute, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Vafa Rahimi-MovagharSina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Mahmoud YousefifardPhysiology Research Center, Iran University of Medical Sciences, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Spinal cord injury (SCI) produces serious neurological and medical problems. Resveratrol (RES), a natural polyphenol, possesses anti-inflammatory and antioxidant characteristics and has revealed neuroprotective ability in central nervous system diseases. This study investigated the therapeutic potential of RES in rat, mouse, and rabbit SCI models. Methods: Articles were identified from Medline, Embase, Scopus, and Web of Science until April 25, 2025. Studies evaluating RES with SCI models were included. Main results were locomotor function, inflammation, oxidative stress, apoptosis, and neuronal survival. Random-effects meta-analysis showed standardized mean differences (SMDs) and their Results: Twenty-six studies were included. RES improved locomotor function (SMD = 3.41, Conclusion: In preclinical SCI models, RES is a promising neuroprotective agent. This suggests that further research is warranted regarding the potential role of RES in SCI treatment.

Indexed as

InflammationNeuroprotectionOxidative stressResveratrolSpinal cord injury

Identifiers

PMID42829558
PMCPMC13633524

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.