ReviewCureus2026
A Layered Framework for Biological Aesthetics: A Narrative Review of Regenerative Medicine in Cosmetic Science.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biological aesthetics applies regenerative substances, including platelet-rich fibrin, mesenchymal stem cells, and fat-derived biological matrices, with emerging adjunctive roles for peptides and exosomes. These approaches have gained attention because of their potential regenerative and biocompatible properties. However, comparative safety, clinical effectiveness, and durability remain uncertain because the available evidence is heterogeneous and, for several modalities, limited to preclinical studies or small clinical investigations. A layered approach addressing bone, fascia, fat, dermis, and epidermis is proposed as a framework for studying age-related changes across multiple tissue planes, but it has not been validated as a clinical treatment protocol. Challenges remain regarding regulatory clarity, product standardization, dosing, safety, and long-term clinical validation. This narrative review summarizes the biological basis, available clinical evidence, regulatory limitations, and research gaps associated with major regenerative agents and presents the multilayered model as a hypothesis-generating framework for future research.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.