Evidence map›Paper›PMID 42829446›Full record

ArticleVeterinary research2026

Cooperation between Adh and OR5M11 contributes to the lung pathogenicity of Actinobacillus pleuropneumoniae by facilitating the NLRP3-mediated inflammatory response.

Bo Wen, Xiaoli Yin, Xinhe Zhang, Chunling Zhu, Xiaofeng Li, Yilin Bai, Huarun Sun, Zhiyi Liu, Shuwen Ji, Ruibiao Wang and 9 more

Abstract read
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In one paragraph

Article in Veterinary research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

19 authors.

Bo Wen *Henan Institute of Science and Technology, the Pingyuan Laboratory, Xinxiang, China.
Xiaoli Yin *Henan Institute of Science and Technology, the Pingyuan Laboratory, Xinxiang, China.
Xinhe Zhang *Henan Institute of Science and Technology, the Pingyuan Laboratory, Xinxiang, China.
Chunling ZhuHenan Institute of Science and Technology, the Pingyuan Laboratory, Xinxiang, China.
Xiaofeng LiHenan Institute of Science and Technology, the Pingyuan Laboratory, Xinxiang, China.
Yilin BaiSchool of Agricultural Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Huarun SunHenan Institute of Science and Technology, the Pingyuan Laboratory, Xinxiang, China.
Zhiyi LiuHenan Institute of Science and Technology, the Pingyuan Laboratory, Xinxiang, China.
Shuwen JiHenan Institute of Science and Technology, the Pingyuan Laboratory, Xinxiang, China.
Ruibiao WangHenan Institute of Science and Technology, the Pingyuan Laboratory, Xinxiang, China.
Chenru YuHenan Institute of Science and Technology, the Pingyuan Laboratory, Xinxiang, China.
Jiaqi WangHenan Institute of Science and Technology, the Pingyuan Laboratory, Xinxiang, China.
Longfei ZhangHenan Institute of Science and Technology, the Pingyuan Laboratory, Xinxiang, China.
Jiyuan ShenHenan Institute of Science and Technology, the Pingyuan Laboratory, Xinxiang, China.
Jianhe HuHenan Institute of Science and Technology, the Pingyuan Laboratory, Xinxiang, China.
Yueyu BaiHenan Institute of Science and Technology, the Pingyuan Laboratory, Xinxiang, China.
Huihui ZhangHenan Institute of Science and Technology, the Pingyuan Laboratory, Xinxiang, China.
Ke DingHenan Institute of Science and Technology, the Pingyuan Laboratory, Xinxiang, China. keding19@163.com.
Lei WangHenan Institute of Science and Technology, the Pingyuan Laboratory, Xinxiang, China. wlei_007@163.com.

Funding

College Students' Innovation and Entrepreneurship Training Program 202410467024Henan Provincial Science and Technology Research Project 252102110045Key Research and Development Project of Henan Province 241111110100National Key R&D Program of China 2021YFD1301200Outstanding Youth Foundation of He'nan Scientific Committee 222300420043Science and Tech- nology Innovative Research Team in Higher Educational Institutions of Henan Province 24IRTSTHN035the joint fund of science and technology research and development plan in Henan province 225200810044the National Natural Science Foundation of China 32172862
6 · The paper itself

Abstract

Actinobacillus pleuropneumoniae (A. pleuropneumoniae) is the etiologic agent of porcine pleuropneumonia, a severe respiratory disease characterized by hemorrhagic, necrotizing lung lesions that cause significant economic losses on the global swine industry. However, the molecular mechanisms underlying the lung pathogenicity of A. pleuropneumoniae remain unclear. Here we demonstrate that A. pleuropneumoniae infection induces lung injury through activating the NLRP3-mediated inflammatory response mediated by the YadA-like head region (Adh) of Apa1, a bacterial adhesin that mediates attachment to host cells. Importantly, we show that Adh triggers the NLRP3-mediated inflammatory response by engaging olfactory receptor family 5 subfamily M member 11 (OR5M11), a host receptor previously shown to interact with Adh. Furthermore, OR5M11 contributes to the Adh-activated inflammatory response by promoting mitochondrial DNA release. Taken together, our results provide new insights into the pathogenesis of A. pleuropneumoniae, particularly regarding NLRP3-mediated inflammatory pathology.

Indexed as

Actinobacillus InfectionsActinobacillus pleuropneumoniaeAdhesins, BacterialNLR Family, Pyrin Domain-Containing 3 ProteinSwine DiseasesAnimalsInflammationLungSwineAdhesins, BacterialNLR Family, Pyrin Domain-Containing 3 ProteinActinobacillus pleuropneumoniaeAdhhyperinflammationlung injuryNLRP3OR5M11

Identifiers

PMID42829446
PMCPMC13633639

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.