ArticleCell communication and signaling : CCS2026
Junctional plakoglobin regulates intestinal epithelial cell proliferation via MAPK/ERK signaling.
Article in Cell communication and signaling : CCS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Junctional plakoglobin (JUP) is a desmosomal protein essential for epithelial tissue integrity and epithelial-immune cell crosstalk. Although JUP has been implicated in inflammatory processes, its role in intestinal epithelial repair remains unclear. In vitro, loss of JUP in Caco-2 monolayers and non-transformed intestinal organoids markedly accelerated wound closure, driven by enhanced epithelial cell migration and proliferation. RNA sequencing-based pathway analysis of organoids revealed activation of MAPK/ERK signaling following JUP deficiency. This effect was corroborated by increased ERK phosphorylation in Western blot analyses. In line with that, pharmacological inhibition of ERK abrogated the accelerated wound closure, confirming that MAPK/ERK signaling is critical for the phenotype. To further examine the relevance in vivo, we used an inducible, intestine-specific JUP knockout mouse model (iVilCreER
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