Evidence map›Paper›PMID 42828729›Full record

ArticleGut microbes2026

Discovery of dietary polyphenols targeting the autoinducer-2 quorum sensing system of pathogenic bacteria.

Shengbo Wu, Peng Zhang, Manman Wang, Xue Xiao, Hongyu Jin, Hongrui Zhang, Danlei Chen, Xiaoli Liu, Juane Lu, Daoguang Tian and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Shengbo WuState Key Laboratory of Synthetic Biology, Key Laboratory of Systems Bioengineering (Ministry of Education), School of Synthetic Biology and Biomanufacturing, Tianjin University, Tianjin, China.ORCID 0000-0001-7497-2935
Peng ZhangState Key Laboratory of Synthetic Biology, Key Laboratory of Systems Bioengineering (Ministry of Education), School of Synthetic Biology and Biomanufacturing, Tianjin University, Tianjin, China.
Manman WangState Key Laboratory of Synthetic Biology, Key Laboratory of Systems Bioengineering (Ministry of Education), School of Synthetic Biology and Biomanufacturing, Tianjin University, Tianjin, China.
Xue XiaoState Key Laboratory of Synthetic Biology, Key Laboratory of Systems Bioengineering (Ministry of Education), School of Synthetic Biology and Biomanufacturing, Tianjin University, Tianjin, China.
Hongyu JinState Key Laboratory of Synthetic Biology, Key Laboratory of Systems Bioengineering (Ministry of Education), School of Synthetic Biology and Biomanufacturing, Tianjin University, Tianjin, China.
Hongrui ZhangState Key Laboratory of Synthetic Biology, Key Laboratory of Systems Bioengineering (Ministry of Education), School of Synthetic Biology and Biomanufacturing, Tianjin University, Tianjin, China.
Danlei ChenZhejiang Institute of Tianjin University (Shaoxing), Shaoxing, China.ORCID 0000-0003-3738-3351
Xiaoli LiuState Key Laboratory of Synthetic Biology, Key Laboratory of Systems Bioengineering (Ministry of Education), School of Synthetic Biology and Biomanufacturing, Tianjin University, Tianjin, China.
Juane LuState Key Laboratory of Synthetic Biology, Key Laboratory of Systems Bioengineering (Ministry of Education), School of Synthetic Biology and Biomanufacturing, Tianjin University, Tianjin, China.
Daoguang TianState Key Laboratory of Synthetic Biology, Key Laboratory of Systems Bioengineering (Ministry of Education), School of Synthetic Biology and Biomanufacturing, Tianjin University, Tianjin, China.
Hao WuZhejiang Institute of Tianjin University (Shaoxing), Shaoxing, China.
Qinggele CaiyinState Key Laboratory of Synthetic Biology, Key Laboratory of Systems Bioengineering (Ministry of Education), School of Synthetic Biology and Biomanufacturing, Tianjin University, Tianjin, China.
Fei GuoSchool of Computer Science and Engineering, Central South University, Changsha, China.
Xiaolong LiuDepartment of Biochemistry, University of Oxford, Oxford, UK.
Aidong YangDepartment of Engineering Science, University of Oxford, Oxford, UK.ORCID 0000-0001-5974-247X
Mingzhang WenState Key Laboratory of Synthetic Biology, Key Laboratory of Systems Bioengineering (Ministry of Education), School of Synthetic Biology and Biomanufacturing, Tianjin University, Tianjin, China.
Jianjun QiaoState Key Laboratory of Synthetic Biology, Key Laboratory of Systems Bioengineering (Ministry of Education), School of Synthetic Biology and Biomanufacturing, Tianjin University, Tianjin, China.ORCID 0000-0002-8126-2074

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Targeting autoinducer-2 (AI-2) quorum sensing (QS) systems with dietary compounds represents a promising strategy to combat pathogens, yet mechanisms remain elusive. Here, we develop a machine learning-driven framework combining computational screening with multi-level experimental analysis to identify AI-2 quorum sensing interference molecules (QSIMs). A graph neural network (GNN)-based classifier (AI2IMpred) screens over 7000 phytochemicals and identifies dietary polyphenols as potent QSIMs. Using

Indexed as

Anti-Bacterial AgentsHomoserineLactonesPolyphenolsQuorum SensingSalmonella typhimuriumBacterial ProteinsCarbon-Sulfur LyasesCarrier ProteinsEscherichia coliEscherichia coli ProteinsGene Expression Regulation, BacterialHumansMolecular Docking SimulationPseudomonas aeruginosaAnti-Bacterial AgentsBacterial ProteinsCarbon-Sulfur LyasesCarrier ProteinsEscherichia coli ProteinsHomoserineLactonesLsrB protein, E coliLuxS protein, BacteriaN-octanoylhomoserine lactonePolyphenolsantibiotic resistancedietary interventionFood is medicinepathogenic bacteriapolyphenolsquorum sensing

Identifiers

PMID42828729
PMCPMC13644630

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.