ArticleJapanese journal of radiology2026
Atypical ovarian fibroma and thecoma mimicking malignancy: clue for differentiation from malignant solid tumors.
Article in Japanese journal of radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the characteristic findings of ovarian fibroma and thecoma (FT) with atypical magnetic resonance imaging (MRI) findings that mimic malignancy and to validate the improvement in diagnostic performance in differentiating between FTs and malignant solid tumors. MATERIALS AND
methodsThis retrospective study included 114 patients (119 lesions: 34 FT and 85 malignant tumors) with pathologically confirmed solid ovarian tumors who underwent preoperative MRI. Signal intensity on T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI) with apparent diffusion coefficient (ADC) maps, and time-intensity curves from dynamic contrast-enhanced MRI (DCE-MRI) were evaluated. FT lesions showing low signal intensity on both T2WI and DWI were defined as classic, whereas others were considered atypical. The diagnostic performance of combined imaging findings was also assessed. A reader study was also performed by three radiologists.
resultsAmong the FT lesions, 55.9% demonstrated intermediate signal intensity on T2WI, and 32.4% showed diffusion restriction. Atypical FT accounted for 56% of all FT cases. The combination of T2WI and DWI showed high specificity (98.8%) but low sensitivity (44.1%) for diagnosing FT as benign. In contrast, for the diagnosis of benign lesions, the combination of T2WI and DCE-MRI demonstrated superior diagnostic performance, with a sensitivity, specificity, positive predictive value, and negative predictive value of 84.0%, 95.9%, 87.5%, and 94.6%, respectively. Reader performance improved when the combined interpretation of T2WI and DCE-MRI findings was emphasized. Using this approach, the estimated misdiagnosis rate of FT as malignant decreased from approximately 40% to 16%.
conclusionAtypical FT frequently mimics malignant ovarian tumors on MRI. The combination of T2WI and DCE-MRI findings provides the best diagnostic performance and significantly reduces misdiagnosis. However, a subset of FT remains indistinguishable from malignancy, highlighting the need for careful interpretation.
Indexed as
Identifiers
42828692What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.