Evidence map›Paper›PMID 42828676›Full record

ArticleDermatology and therapy2026

Lifestyle-Driven Phenotypes in Sensitive Skin: A Cross-Sectional, Multicenter Study Across Urbanization Tiers.

Jade Conway, Irina Berlin, Céline Blanché, Mathieu Grivet-Seyve, Haw Diann Wai, Nicolas Joly Tonetti, Adam Friedman, Krzysztof Piotrowski, Nadège Lachmann, Aaron S Farberg

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Article in Dermatology and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jade ConwayReveal Research Institute, 2110 Research Row, Suite 310B, Dallas, TX, 75235, USA. jconway@revealinstitute.com.
Irina BerlinGalderma R&D, Lausanne, Switzerland.
Céline BlanchéGalderma R&D, Barcelona, Spain.
Mathieu Grivet-SeyveGalderma R&D, Dallas, TX, USA.
Haw Diann WaiGalderma R&D, Singapore, Singapore.
Nicolas Joly TonettiGalderma R&D, Lausanne, Switzerland.
Adam FriedmanDepartment of Dermatology, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Krzysztof PiotrowskiSensitive Skincare Faculty, Galderma R&D, ZUG, Switzerland.
Nadège LachmannSensitive Skincare Faculty, Galderma R&D, ZUG, Switzerland.
Aaron S FarbergReveal Research Institute, 2110 Research Row, Suite 310B, Dallas, TX, 75235, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSensitive skin is shaped by intrinsic physiology and environmental exposures, yet how concurrent lifestyle factors modulate its expression remains poorly characterized. This study examined how differing environmental and lifestyle conditions influence sensitive skin phenotypes through clinical evaluation, biophysical measurements, and biomarker profiling.

methodsA cross-sectional, multicenter study enrolled 151 women (aged 35-50 years) into three groups based on environmental and lifestyle factors: non-sensitive highly urbanized lifestyle (NS-1), sensitive skin highly urbanized lifestyle (SSS-1), and sensitive skin moderately urbanized lifestyle (SSS-2). Lifestyle classification was defined using three concomitantly considered indicators: pollution exposure, sleep quality, and psychological stress. Tier 1 PM

resultsIn the intrinsic-biology comparison (SSS-1 vs. NS-1), sensitive skin was associated with significantly elevated prostaglandin E

conclusionIn this cross-sectional cohort, sensitive skin was associated with elevated protein carbonylation and greater pigmentary reactivity relative to non-sensitive skin under matched highly urbanized conditions. PGE

Indexed as

DermatologyExposomeLifestyleNeurogenic inflammationOxidative stressPigmentationProstaglandin E2Protein carbonylationSensitive skin

Identifiers

PMID42828676

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.