ArticleClinical oral investigations2026
Coadministration of fluoride, trimetaphosphate, and quercetin reduces dentin erosive wear in vitro.
Article in Clinical oral investigations, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
objectivesTo evaluate the effect of solutions containing quercetin (QC), sodium trimetaphosphate (TMP), and fluoride (F), in different combinations, on dentin erosive wear (DEW) in vitro. MATERIALS AND
methodsBovine root dentin blocks were randomly divided into seven experimental groups (n = 28/group): deionized water (control); 500 ppm F (500F); 1100 ppm F (1100F); 5000 ppm F (5000F); 1100 F + 0.03% QC (F + QC); 1100 F + 1% TMP (F + TMP); and 1100 F + 1% TMP + 0.03% QC ("EXP" - experimental). Blocks were treated twice/day and subjected to four daily erosive challenges for five days (0.05 M citric acid, pH 3.2, 90 s), either erosion only (ERO) or erosion plus abrasion by brushing (ERO + ABR). The samples were analyzed by profilometry and computed X-ray microtomography, and the data were analyzed by 2-way ANOVA followed by Fisher's LSD post hoc test.
resultsUnder both conditions, a dose-response relationship was observed between F concentration and all variables, with the lowest values for 5000F and EXP. Under ERO, only 5000F showed lower DEW than 1100F; under ERO + ABR, all TMP and/or QC-containing solutions reduced DEW compared with 1100F, with a similar trend for mineral loss and depth of mineral loss, most notably for 5000F and EXP.
conclusionsAdding QC or TMP to 1100F produced modest additional protection, while their combination yielded a significant additive effect comparable to that of a solution with a five-fold higher F concentration. CLINICAL RELEVANCE: Possibility of reducing fluoride concentration in preventive formulations with an effect similar to that of high-concentration formulations against DEW.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.