ReviewOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2026
Interaction between vitamin D and the growth hormone/insulin-like growth factor 1 axis in children: a systematic review and meta-analysis.
Review in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThis article presents a systematic review and meta-analysis of relevant studies to clarify the relationship between vitamin D and the growth hormone/insulin-like growth factor 1(GH/IGF-1) axis.
methodsPubMed/MEDLINE, Web of Science, SCOPUS, Embase, and CNKI databases were searched. Relevant articles on the effect of vitamin D on IGF-1 levels were reviewed. The effect of recombinant human growth hormone supplementation on 25-hydroxyvitamin D[25(OH)D] levels was meta-analyzed, and subgroup analyses were conducted.
resultsIGF-1 levels increased after vitamin D supplementation. Vitamin D combined with rhGH therapy resulted in higher IGF-1 levels than rhGH alone. The meta-analysis included 24 studies. Vitamin D levels increased after rhGH treatment (WMD: 5.83 ng/mL, 95% CI: 3.72 to 7.94, I² = 99%, p < 0.00001), both in children with GHD (WMD: 7.78 ng/mL, 95% CI: 2.02 to 13.55, I² = 99%, p = 0.008) and ISS(WMD: 2.74 ng/mL, 95% CI: 1.25 to 4.23, I² = 98%, p = 0.0003). Results showed that vitamin D levels in children with growth hormone deficiency (GHD) were significantly lower than those in healthy children (WMD: -8.69 ng/mL, 95% CI: -15.91 to -1.46, I² = 96%, p = 0.02). There was no significant difference in vitamin D levels between children with idiopathic short stature (ISS) and healthy children (WMD: -3.86 ng/mL, 95% CI: -7.70 to -0.01, I² = 98%, p = 0.05). However, vitamin D levels in short children remained lower than those in healthy children after rhGH treatment (WMD: -1.68 ng/mL, 95% CI: -2.53 to -0.82, I² = 84%, p = 0.0001).
conclusionThe increase in IGF-1 levels following vitamin D supplementation should be accounted for in clinical practice when evaluating IGF-1 values to optimize the diagnosis of short stature causes. Children with GHD have lower vitamin D levels, and rhGH supplementation can increase vitamin D levels. Combined vitamin D and rhGH therapy can better promote growth and development in children with short stature.
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