Evidence map›Paper›PMID 42828364›Full record

ArticleACS pharmacology & translational science2026

Insights into the Mechanism of Action of Phosphoantigen Prodrugs on Vγ9Vδ2 T Cell Activation.

Maria Sharif, Claudia M A Pinna, Kamila Rakhimova, Taher E Taher, Andrew D Beggs, Youcef Mehellou, Benjamin E Willcox

Abstract read
In one paragraph

Article in ACS pharmacology & translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Maria SharifCancer Immunology and Immunotherapy Centre, College of Medicine and Health, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
Claudia M A PinnaSchool of Medical Sciences, Department of Cancer and Genomic Sciences, College of Medicine and Health, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.ORCID https://orcid.org/0000-0002-5618-7842
Kamila RakhimovaSchool of Medical Sciences, Department of Cancer and Genomic Sciences, College of Medicine and Health, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
Taher E TaherCancer Immunology and Immunotherapy Centre, College of Medicine and Health, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
Andrew D BeggsSchool of Medical Sciences, Department of Cancer and Genomic Sciences, College of Medicine and Health, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
Youcef MehellouSchool of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff CF10 3NB, U.K.ORCID https://orcid.org/0000-0001-5720-8513
Benjamin E WillcoxCancer Immunology and Immunotherapy Centre, College of Medicine and Health, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.ORCID https://orcid.org/0000-0002-6113-2109

Funding

Wellcome Trust
6 · The paper itself

Abstract

The activation of Vγ9Vδ2 T cells has emerged as a promising modality in cancer immunotherapy. Phosphate and phosphonate prodrugs of Vγ9Vδ2 T cell phosphoantigens have been developed as potent activators of Vγ9Vδ2 T cells that are capable of effectively facilitating lysis of a range of cancer cells

Indexed as

cancermechanismprodrugProPAgenuptakeVγ9Vδ2 T cells

Identifiers

PMID42828364
PMCPMC13632888

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.