Evidence map›Paper›PMID 42828349›Full record

ArticleACS pharmacology & translational science2026

Regulation of Diverse Endogenous Metabolic and Signaling Pathways by UDP-Glucuronosyltransferases (UGTs) Revealed by Metabolomics of Knockout Mice.

Kian Falah, Jiarun Liu, Nghia Nguyen, Shujuan Chen, Robert H Tukey, Sanjay K Nigam

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS pharmacology & translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kian FalahDepartment of Pediatrics, University of California, La Jolla, California 92093, United States.ORCID https://orcid.org/0009-0005-6757-4118
Jiarun LiuDepartment of Pediatrics, University of California, La Jolla, California 92093, United States.
Nghia NguyenDepartment of Pharmacology, University of California, La Jolla, California 92093, United States.
Shujuan ChenDepartment of Pharmacology, University of California, La Jolla, California 92093, United States.
Robert H TukeyDepartment of Pharmacology, University of California, La Jolla, California 92093, United States.
Sanjay K NigamDepartment of Pediatrics, University of California, La Jolla, California 92093, United States.

Funding

The Role of OAT1 in UremiaR01DK109392 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NIGAM, SANJAY K · 2017 to 2025
$3.8M
Severe neonatal hyperbilirubinemia (SNH) and the expression of UDP-glucuronosyltransferase 1A1 (UGT1A1) play key roles in the development of necrotizing enterocolitis (NEC)R01DK136599 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Robert H Tukey · 2023 to 2026
$2.5M
NIDDK NIH HHS R01 DK109392NIDDK NIH HHS R01 DK136599
6 · The paper itself

Abstract

Uridine 5'-diphospho-glucuronosyltransferase (UGT) enzymes play a critical role in hepatic and other metabolism of endogenous and exogenous small molecules. The addition of glucuronic acid via UGT increases the polarity and subsequent solubility of small molecules, helping direct them for biliary excretion and renal excretion by organic anion transporter OAT3 (SLC22A8). Mutations in UGTs are associated with disorders in biliary metabolism (e.g., Gilbert's syndrome, Crigler-Najjar syndrome). Here, we used comprehensive serum metabolomic profiling of pan

Indexed as

crigler-najjar syndromegut-liver-kidney axisorgan crosstalkremote sensing and signaling theorySLC22A8UGT1

Identifiers

PMID42828349
PMCPMC13632887

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.