ArticleJournal of bone and joint infection2026
External validation of the KLIC score and development of a novel prediction model for debridement, antibiotics, and implant retention failure in prosthetic joint infection: a multicentre cohort study.
Article in Journal of bone and joint infection, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Appropriate estimation of the risk of failure after debridement, antibiotics, and implant retention (DAIR) may provide useful prognostic information in patients with prosthetic joint infection (PJI). We aimed to externally validate the Kidney, Liver, Index surgery, Cemented prosthesis, C-reactive protein (KLIC) score and to develop and internally validate a new prediction model based on variables available before DAIR. We conducted a retrospective multicentre cohort study using medical record data from adults with PJI treated with DAIR across eight Spanish centres between 2006 and 2023, with a minimum 12-month follow-up. Predictors were analysed using a generalized linear mixed-effects model, with assessment of discrimination, calibration, and bootstrap internal validation. Among 224 patients, 121 (54 %) experienced DAIR failure. The final model retained revision prosthesis, Charlson Comorbidity Index
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