Evidence map›Paper›PMID 42828275›Full record

ArticleCerebral circulation - cognition and behavior2026

Older adults in more disadvantaged neighborhoods exhibit brain vascular dysfunction.

Kevin W Law, Allison C Engstrom, Trevor Lohman, Melanie Quiring, Arunima Kapoor, John Paul M Alitin, Danny J J Wang, Aimée Gaubert, Kathleen Rodgers, Elizabeth Head and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebral circulation - cognition and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kevin W LawLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Allison C EngstromDepartment of Psychological Science, University of California, Irvine, Irvine, CA, USA.
Trevor LohmanDepartment of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Melanie QuiringLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Arunima KapoorDepartment of Psychological Science, University of California, Irvine, Irvine, CA, USA.
John Paul M AlitinLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Danny J J WangMark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Aimée GaubertLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Kathleen RodgersCenter for Innovations in Brain Science, Department of Pharmacology, University of Arizona, Tucson, AZ, USA.
Elizabeth HeadDepartment of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, USA.
Celina I ValenciaCenter for Innovations in Brain Science, Department of Pharmacology, University of Arizona, Tucson, AZ, USA.
Jillian L JoyceLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Farrah FerrerLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Daniel A NationLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.

Funding

Vascular Contributions to Dementia and Genetic Risk Factors for Alzheimer's DiseaseP01AG052350 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Daniel A Nation, ARTHUR W TOGA · 2016 to 2026
$28.4M
USCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI · 2020 to 2026
$27.8M
Locus Coeruleus Imaging Markers in Preclinical Alzheimers disease, Cerebrovascular Disease and Cognitive DeclineR01AG082073 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BONDI, MARK W, MATHER, MARA · 2023 to 2025
$4.9M
Endothelial progenitor cells and neurovascular injury in the aging brainR01AG064228 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Daniel A Nation · 2019 to 2026
$4.5M
NIA NIH HHS P01 AG052350NIA NIH HHS P30 AG066530NIA NIH HHS R01 AG064228NIA NIH HHS R01 AG082073
6 · The paper itself

Abstract

Neighborhood disadvantage is a risk factor for dementia, but the mechanisms involved are not well understood. In this study, we explored the relationship between neighborhood deprivation and whole-brain cerebrovascular reactivity (CVR) in 132 older adults without a history of clinical stroke or dementia. Participants underwent brain MRI and venipuncture. Relative neighborhood deprivation was quantified using the Area Deprivation Index. Spontaneous CVR was calculated as the percent change in resting cerebral blood flow per unit change in end-tidal CO

Indexed as

Brain healthCerebrovascular reactivityHealth disparitiesNeighborhood disadvantageVascular dementia

Identifiers

PMID42828275
PMCPMC13632079

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.