Evidence map›Paper›PMID 42828209›Full record

ArticleFrontiers in nutrition2026

Acupoint catgut embedding exerts node-dependent effects on leptin resistance-related signaling and the ghrelin-GOAT pathway in obese mice.

Qiwang Yang, Han Yang, Jinjiao Zhang, Nenggui Xu, Chuanwu Zhu, Wei Yi, Hanqing Huang

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Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Qiwang Yang *Department of Rehabilitation Medicine, The Fifth Affiliated Hospital of Southern Medical University, Guangzhou, China.
Han Yang *Medical College of Acupuncture Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China.
Jinjiao Zhang *The First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China.
Nenggui XuMedical College of Acupuncture Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China.
Chuanwu ZhuSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
Wei YiMedical College of Acupuncture Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China.
Hanqing HuangDepartment of Plastic and Aesthetic Surgery, The People's Hospital of Baoan Shenzhen, The Second Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Obesity is a major metabolic health problem with limited effective treatments. Acupoint catgut embedding (ACE) has shown therapeutic potential; however, its underlying mechanisms remain unclear. This study aimed to investigate the effects of ACE on leptin resistance and the Ghrelin-GOAT pathway in obese mice. Methods: Diet-induced obesity was established in C57BL/6 J mice. A total of 51 mice were included in the final analysis across six groups: normal control, obese model control, ST36 sham ACE, ST36 verum ACE, ST25 ACE, and ST25 + ST36 ACE. ACE was administered once weekly for 5 weeks. Body weight, Lee's index, and daily food intake were recorded. Serum and cerebrospinal fluid (CSF) leptin levels were measured to assess peripheral and central leptin availability. Hypothalamic SOCS3 and PTP1B protein expression and POMC/NPY mRNA levels were evaluated. Ghrelin-related indicators in gastric tissue and hypothalamus were also assessed. Results: At week 1, body weight and Lee's index were lower in the ST36 verum ACE group than in the ST25 + ST36 group ( Conclusion: ACE may increase central leptin availability, downregulate SOCS3 and PTP1B, regulate hypothalamic POMC/NPY expression, and modulate the ghrelin-GOAT pathway, supporting a node-dependent, multi-target mechanism underlying its anti-obesity effects.

Indexed as

acupoint catgut embeddingghrelin-GOAT pathwayhypothalamusleptin resistanceobesity

Identifiers

PMID42828209
PMCPMC13631939

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.