Evidence map›Paper›PMID 42828163›Full record

ArticleFrontiers in immunology2026

Enrichment of the TRIM21-IgG complex in placental villi during HIV-1 infection.

Beatriz Noronha Campo, Emanuella Sarmento Alho de Sousa, Nátalli Zanete Pereira, Anna Julia Pietrobon, Helaine Maria Besteti Pires Mayer Milanez, Mirian Nacagami Sotto, Gabriela Domingues Mattos, Gabriel Benevides Simões, Daniel Pereira Sousa, Marina de Mello Naresse and 2 more

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Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Beatriz Noronha CampoLaboratory of Medical Investigation 56, Department of Dermatology, University of São Paulo Medical School, Institute of Tropical Medicine, São Paulo, Brazil.
Emanuella Sarmento Alho de SousaLaboratory of Medical Investigation 56, Department of Dermatology, University of São Paulo Medical School, Institute of Tropical Medicine, São Paulo, Brazil.
Nátalli Zanete PereiraLaboratory of Medical Investigation 56, Department of Dermatology, University of São Paulo Medical School, Institute of Tropical Medicine, São Paulo, Brazil.
Anna Julia PietrobonLaboratory of Medical Investigation 56, Department of Dermatology, University of São Paulo Medical School, Institute of Tropical Medicine, São Paulo, Brazil.
Helaine Maria Besteti Pires Mayer MilanezDepartment of Tocoginecologia, State University of Campinas, Campinas, Brazil.
Mirian Nacagami SottoLaboratory of Medical Investigation 50, Department of Pathology, University of São Paulo Medical School, São Paulo, Brazil.
Gabriela Domingues MattosLaboratory of Medical Investigation 56, Department of Dermatology, University of São Paulo Medical School, Institute of Tropical Medicine, São Paulo, Brazil.
Gabriel Benevides SimõesLaboratory of Medical Investigation 56, Department of Dermatology, University of São Paulo Medical School, Institute of Tropical Medicine, São Paulo, Brazil.
Daniel Pereira SousaLaboratory of Medical Investigation 56, Department of Dermatology, University of São Paulo Medical School, Institute of Tropical Medicine, São Paulo, Brazil.
Marina de Mello NaresseDepartment of Tocoginecologia, State University of Campinas, Campinas, Brazil.
Vinícius Nunes Cordeiro LealDepartment of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Maria Notomi SatoLaboratory of Medical Investigation 56, Department of Dermatology, University of São Paulo Medical School, Institute of Tropical Medicine, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Innate immunity constitutes a pivotal defense mechanism protecting the maternal-fetal interface against viral pathogens. However, the dynamics of placental immunity in pregnant women with chronic HIV-1 infection undergoing suppressive antiretroviral therapy (ART) remain poorly understood. Tripartite motif (TRIM) family proteins act as critical host restriction factors or indirect regulators of antiviral pathways through ubiquitination cascades. Objectives: In this study, we profiled the transcriptional expression of prominent antiviral Methods: Quantitative real-time PCR in the decidua and villi was performed in both the decidual and chorionic villi compartments of HIV-1-infected parturient women compared to HC. Gene network was generated using GeneMANIA was assessed to identify functionally related genes. Given that TRIM21 classically intercepts antibody-coated target complexes, we evaluated its spatial intersection with maternal humoral components via immunofluorescence using a TissueGnostics scanning confocal microscope. Results: Quantitative real-time PCR revealed compartment-specific alterations, with a significant upregulation of Conclusions: Taken together, our findings unveil a localized upregulation of antiviral

Indexed as

Chorionic VilliHIV-1HIV InfectionsImmunoglobulin GPregnancy Complications, InfectiousRibonucleoproteinsAdultDeciduaFemaleHumansImmunity, InnatePregnancySS-A AntigenTRIM21 ProteinTripartite Motif ProteinsImmunoglobulin GRibonucleoproteinsSS-A AntigenTRIM21 ProteinTripartite Motif Proteinsantiretroviral therapyHIV-1host restriction factorsinnate immunitymaternal-fetal interfaceplacentaTRIM21

Identifiers

PMID42828163
PMCPMC13631741

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