Evidence map›Paper›PMID 42828110›Full record

ArticleMaterials today. Bio2026

Bioactive polythioctic acid-engineered ropivacaine alleviates bone cancer pain through prolonged analgesia and multi-functional neuroprotection.

Ziping Wu, Yucen Zhang, Yan Guo, Yueying Wang, Zhen Wang, Zhuo Yang, Dongmei Guo, Chao Xu, Boyuan Gu, Haoyu Zheng and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ziping WuCollege of Basic Medical Sciences, The Medical Basic Research Innovation Center of Airway Disease in North China, Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun, 130021, China.
Yucen ZhangDepartment of Anesthesiology, The Fifth Clinical Medical College, Inner Mongolia Medical University, Hohhot, Inner Mongolia, 010030, China.
Yan GuoDepartment of Anesthesiology, The Fifth Clinical Medical College, Inner Mongolia Medical University, Hohhot, Inner Mongolia, 010030, China.
Yueying WangState Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases and Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041, China.
Zhen WangCollege of Basic Medical Sciences, The Medical Basic Research Innovation Center of Airway Disease in North China, Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun, 130021, China.
Zhuo YangCollege of Basic Medical Sciences, The Medical Basic Research Innovation Center of Airway Disease in North China, Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun, 130021, China.
Dongmei GuoDepartment of Anesthesiology, Inner Mongolia People's Hospital, Hohhot, Inner Mongolia, 010017, China.
Chao XuDepartment of Anesthesiology, Inner Mongolia People's Hospital, Hohhot, Inner Mongolia, 010017, China.
Boyuan GuHohhot First Hospital, Hohhot, Inner Mongolia, 010030, China.
Haoyu ZhengHohhot First Hospital, Hohhot, Inner Mongolia, 010030, China.
Yali YanDepartment of Anesthesiology, The Fifth Clinical Medical College, Inner Mongolia Medical University, Hohhot, Inner Mongolia, 010030, China.
Ming ZhangCollege of Basic Medical Sciences, The Medical Basic Research Innovation Center of Airway Disease in North China, Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun, 130021, China.
Dan ShaoState Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases and Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041, China.
Li ChenCollege of Basic Medical Sciences, The Medical Basic Research Innovation Center of Airway Disease in North China, Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun, 130021, China.
Aitao WangHohhot Stomatological Hospital, Inner Mongolia Autonomous Region Stomatological Hospital, Hohhot, Inner Mongolia, 010110, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone cancer pain (BCP), driven by tumor-induced bone destruction and central sensitization, represents a major clinical challenge. Although ropivacaine (Rop) is a cornerstone for BCP management, it fails to provide prolonged analgesia and neuroprotective benefits. Through RNA transcriptomics and phenotypic analysis in a murine model of metastatic BCP, we show that while Rop rapidly alleviates mechanical and thermal hyperalgesia, it paradoxically exacerbates spinal oxidative stress and neuroinflammation. To address this paradox, we engineered a multifunctional, redox-responsive polymer platform designed to prolong analgesia and mitigate Rop-associated neuronal injury concurrently. Leveraging polythioctic acid (PTA) with a responsive disulfide framework, the encapsulated Rop achieves a sustained release profile to facilitate prolonged analgesia under reductive tumor microenvironment. Meanwhile, the liberated thioctic acid (TA) acts as an antioxidant to ameliorate both neurotoxicity and neuroinflammation. Consequently, the PTA@Rop nanoparticle achieves a 1.6-fold extension of the analgesia window compared to free Rop

Indexed as

Bone cancer painNeuroprotectionPolythioctic acidRopivacaineSustained analgesia

Identifiers

PMID42828110
PMCPMC13631621

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.