Evidence map›Paper›PMID 42828091›Full record

ArticleIJID regions2026

Small-sample antimicrobial resistance surveillance using lot quality assurance sampling in Uganda, Malawi, and Zambia.

Robert Onzima Anguyo, Kennedy Uadiale, Phillip Chilembo, Joyce Chinyama Chilekwa, Elizabeth Ekirapa-Kiracho, Nicholas Feasey, Jerry Ictho, Angelo Lamadrid, Freddy Eric Kitutu, Henry Kajumbula and 13 more

Abstract read
In one paragraph

Article in IJID regions, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Robert Onzima AnguyoLiverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK.
Kennedy UadialeLiverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK.
Phillip ChilemboCentre for Infectious Disease Research in Zambia, Ibex Hill, Lusaka, Zambia.
Joyce Chinyama ChilekwaCentre for Infectious Disease Research in Zambia, Ibex Hill, Lusaka, Zambia.
Elizabeth Ekirapa-KirachoDepartment of Community Health and Behavioural Sciences, Makerere University School of Public Health, Kampala, Uganda.
Nicholas FeaseyLiverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK.
Jerry IcthoDoctors with Africa CUAMM, Kampala, Uganda.
Angelo LamadridLiverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK.
Freddy Eric KitutuDepartment of Community Health and Behavioural Sciences, Makerere University School of Public Health, Kampala, Uganda.
Henry KajumbulaDepartment of Microbiology, Makerere University School of Biomedical Sciences, Kampala, Uganda.
Katayi KazimbayaCentre for Infectious Disease Research in Zambia, Ibex Hill, Lusaka, Zambia.
Peter LochoroDoctors with Africa CUAMM, Kampala, Uganda.
Chrispus MayoraDepartment of Community Health and Behavioural Sciences, Makerere University School of Public Health, Kampala, Uganda.
Pius MukisaDepartment of Community Health and Behavioural Sciences, Makerere University School of Public Health, Kampala, Uganda.
Charles Lubanga NkoloDoctors with Africa CUAMM, Kampala, Uganda.
Thomasena O'ByrneLiverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK.
Marcello PaganoBiostatistics Department, Harvard T.H. Chan School of Public Health, Boston, MA.
Kapambwe MwapeCentre for Infectious Disease Research in Zambia, Ibex Hill, Lusaka, Zambia.
Michelo SimuyandiCentre for Infectious Disease Research in Zambia, Ibex Hill, Lusaka, Zambia.
Hannah BettsLiverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK.
Adam P RobertsLiverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK.
Anjali SharmaCentre for Infectious Disease Research in Zambia, Ibex Hill, Lusaka, Zambia.
Joseph J ValadezLiverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK.

Funding

Wellcome Trust
6 · The paper itself

Abstract

Objectives: We evaluated lot quality assurance sampling (LQAS) adapted for antimicrobial resistance (AMR) surveillance (AMR-LQAS), a small-sample approach designed to classify district AMR prevalence against a clinically meaningful resistance threshold in Uganda, Malawi, and Zambia. Methods: The study was conducted across nine districts/locations, with each country including one urban, one peri-urban, and one rural district/location. Upper and lower resistance thresholds were 20% and 5%, respectively, with predefined misclassification probabilities (α = 0.05, β = 0.10), yielding a minimum sample size of 44 per district. In Uganda, classifications were compared with larger probability samples (n ≥ 240 in each of three districts). Organisms assessed included extended-spectrum beta-lactamase (ESBL)-producing Results: In Uganda, concordance between AMR-LQAS and probability-sample classifications was nine of 12 organism-district comparisons. Across antibiotic-district comparisons, concordance was 46/48, resulting in overall reliability of 92% (55/60 comparisons). Resistance to ciprofloxacin, gentamicin, and trimethoprim-sulfamethoxazole in ESBL-producing Conclusion: AMR-LQAS reliably classified district-level resistance using substantially smaller sample sizes than conventional prevalence surveys, generating actionable subnational information to support antibiotic stewardship and surveillance in low-resource settings.

Indexed as

AMR prevalenceESBL-producing Escherichia coliESBL-producing Klebsiella pneumoniaeLQASMethicillin-resistant Staphylococcus aureus

Identifiers

PMID42828091
PMCPMC13631612

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.