ArticleAvicenna journal of medical biotechnology
Noscapine Induces Apoptosis and Inhibits Invasion in Caco-2 Colon Cancer Cells
Article in Avicenna journal of medical biotechnology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: There are growing evidences related with critical role of non-coding RNAs (lncRNAs), oncogenes, and microRNAs (miRNAs) in pathogenesis and metastatic capacity of Colorectal Cancer (CRC). This study aimed to elucidate the pro-apoptotic and anti-metastatic effect of Noscapine as alkaloid compound in addition its effect on CCAT2, miR-218-5p, MYC, and GLI in Caco-2 CRC cells. Methods: Caco-2 cells were exposed to increasing concentrations of Noscapine (10-100 Results: The MTT assay showed the dose and time dependent attenuation of Caco-2 cells survival rate compared to the control. Comet assay demonstrated significant DNA damage in treated cells. The flow cytometry indicated cell cycle arrest at the G0/G1 phase and late apoptotic and necrotic cell increment. The scratch assay confirmed impaired migration, with markedly reduced wound closure in IC50 treated group. The qRT-PCR showed that in contrast to remarkable up-regulation of miRNA 218 (*p<0.05), the level of CCAT2 (*p<0.05), MYC (**p<0.01) and GLI1 (**p<0.01) was significantly diminished in Noscapine treated cells. Conclusion: Noscapine exhibited anti-proliferative and anti-migratory effects in Caco-2 CRC cells, which are associated with altered expression of
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