Evidence map›Paper›PMID 42827944›Full record

ArticleFrontiers in public health2026

Prevalence, high-risk HPV type profile, and factors associated with high-risk HPV infection among women living with HIV in Kinshasa, Democratic Republic of the Congo.

Julien Neze-Sebakunzi, Anna Maria Doro Altan, Susanna Ceffa, Giovanni Guidotti, Stefano Capparucci, Fausto Ciccacci, Marlène Musikingala, Antoine Nkuba-Ndaye, Jean-Claude Makangara-Cigolo, Jean-Paul Kompany Kisenzele and 3 more

Abstract read
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Article in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Julien Neze-SebakunziService of Microbiology, Department of Medical Biology, Kinshasa University Hospital, University of Kinshasa, Kinshasa, Democratic Republic of Congo.
Anna Maria Doro AltanUniversità degli Studi Link, Rome, Italy.
Susanna CeffaCommunity of Sant'Egidio, DREAM Program Europe, Rome, Italy.
Giovanni GuidottiAzienda Sanitaria Locale (ASL) Roma 1, Rome, Italy.
Stefano CapparucciCommunity of Sant'Egidio, DREAM Program Europe, Rome, Italy.
Fausto CiccacciDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.
Marlène MusikingalaCommunity of Sant'Egidio, DREAM Program DRC, Kinshasa, Democratic Republic of Congo.
Antoine Nkuba-NdayeService of Microbiology, Department of Medical Biology, Kinshasa University Hospital, University of Kinshasa, Kinshasa, Democratic Republic of Congo.
Jean-Claude Makangara-CigoloService of Microbiology, Department of Medical Biology, Kinshasa University Hospital, University of Kinshasa, Kinshasa, Democratic Republic of Congo.
Jean-Paul Kompany KisenzeleService of Microbiology, Department of Medical Biology, Kinshasa University Hospital, University of Kinshasa, Kinshasa, Democratic Republic of Congo.
Trésor Kabeya-MampuelaService of Microbiology, Department of Medical Biology, Kinshasa University Hospital, University of Kinshasa, Kinshasa, Democratic Republic of Congo.
Stefano OrlandoDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.
Steve Ahuka-MundekeService of Microbiology, Department of Medical Biology, Kinshasa University Hospital, University of Kinshasa, Kinshasa, Democratic Republic of Congo.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cervical cancer is one of the most common cancers in women, particularly among women living with HIV. High-risk human papillomavirus (Hr-HPV) is the main causative agent of this cancer, but the prevalence of Hr-HPV infection among women living with HIV in Kinshasa remains poorly documented. The objective of this study was to determine this prevalence and identify associated risk factors. Methods: A cross-sectional study was conducted among women living with HIV aged 25-65 years receiving antiretroviral therapy at the DREAM Center in Kinshasa. Participants were consecutively recruited among eligible women attending the center during the study period. Cervical samples were collected using the Abbott Cervi-Collect kit and analyzed for Hr-HPV genotyping using the Abbott RealTime HPV assay on the m2000 platform, a real-time PCR method detecting HPV-16, HPV-18, and a pooled group of 12 additional high-risk HPV types with an internal β-globin control for sample quality assurance. Sociodemographic and clinical data were collected using structured questionnaires. Results: A total of 436 women were included in the analysis. The prevalence of Hr-HPV infection was 47.7%. Of these, 23.79 % were infected with oncogenic HPV-16 and-18 types (alone or in co-infection with other types). In a logistic regression analysis, WHO clinical stage 3 and 4, duration of antiretroviral therapy for less than 2 years, and HIV viral load greater than or equal to 1,000 copies/ml showed statistically significant associations with Hr-HPV infection, with adjusted ORs of 1.75 (1.16-2.64; Conclusions: This study reveals a high prevalence of Hr-HPV infection among women living with HIV in Kinshasa. Non-16/18 HPV types were predominant, while HPV-16 and HPV-18 were detected in approximately one in four Hr-HPV-positive women. Advanced HIV disease (WHO clinical stages 3 and 4), unsuppressed HIV viral load, and shorter duration of antiretroviral therapy were independently associated with Hr-HPV infection. These findings underscore the potential value of broader HPV vaccine coverage, including higher-valent vaccines, alongside strengthened cervical cancer screening as part of comprehensive cervical cancer prevention strategies.

Indexed as

HIV InfectionsHuman Papillomavirus VirusesPapillomaviridaePapillomavirus InfectionsAdultAgedCross-Sectional StudiesDemocratic Republic of the CongoFemaleGenotypeHumansMiddle AgedPrevalenceRisk FactorsUterine Cervical Neoplasmscervical cancerDemocratic Republic of the Congohigh-risk HPVHIVhuman papillomavirus (HPV)Kinshasawomen living with HIV

Identifiers

PMID42827944
PMCPMC13630942

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.