ArticleFrontiers in oncology2026
Case Report: breast cancer presenting as dermatomyositis.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Cancer-associated dermatomyositis (CADM) is a rare paraneoplastic syndrome characterized by inflammatory myopathy and distinctive cutaneous manifestations. Early recognition of an underlying malignancy is essential for improving patient outcomes. Case presentation: We report the case of a 48-year-old woman who initially presented with dermatomyositis as the first manifestation of breast cancer. She was admitted with progressive dysphagia, violaceous edematous erythema involving the face and neck, and proximal muscle weakness of the extremities. The patient had previously been diagnosed with idiopathic dermatomyositis at another institution and treated with glucocorticoids; however, her symptoms showed no significant improvement. Further evaluation at our hospital revealed markedly elevated muscle enzyme levels. Autoantibody testing demonstrated weak positivity for anti-Jo-1 antibodies and positivity for anti-Ro-52 antibodies. Both skin and muscle biopsies supported the diagnosis of dermatomyositis. Comprehensive malignancy screening subsequently identified invasive carcinoma of the right breast with axillary lymph node metastasis. Following treatment with glucocorticoids combined with two cycles of neoadjuvant chemotherapy consisting of paclitaxel and platinum-based agents, the patient's skin lesions markedly regressed, muscle strength improved, and dysphagia was significantly alleviated. She subsequently underwent radical breast surgery followed by adjuvant radiotherapy, and her condition has remained stable during follow-up. Conclusion: A review of the literature indicates that age >40 years, dysphagia, rapid disease progression, and positivity for anti-transcription intermediary factor 1-gamma a
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