Evidence map›Paper›PMID 42827838›Full record

ArticleAmerican journal of preventive cardiology2026

Effects of PCSK9 inhibitors on coronary atheroma morphology in patients with coronary artery disease treated with statins: a meta-analysis and systematic review.

Priyesh Thakurathi, Agnes S Kim, Michael G Nanna, Khagendra Dahal, Shiva S Aryal, Quinn Pack, Dinesh K Kalra, Raymond G McKay, Paul D Thompson, Andrew M Goldsweig

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of preventive cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Priyesh ThakurathiDepartment of Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA.
Agnes S KimDivision of Cardiology, University of Connecticut, Farmington, CT, USA.
Michael G NannaSection of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT, USA.
Khagendra DahalDivision of Cardiology, University of Connecticut, Farmington, CT, USA.
Shiva S AryalDepartment of Medicine, Jersey City Medical Center, Jersey City, NJ, USA.
Quinn PackDepartment of Cardiovascular Medicine, Baystate Medical Center and Division of Cardiovascular Medicine, University of Massachusetts-Baystate, Springfield, MA, USA.
Dinesh K KalraDivision of Cardiology, University of Louisville, Louisville, Kentucky, USA.
Raymond G McKayHeart and Vascular Institute, Hartford Healthcare, Hartford, Connecticut, USA.
Paul D ThompsonHeart and Vascular Institute, Hartford Healthcare, Hartford, Connecticut, USA.
Andrew M GoldsweigDepartment of Cardiovascular Medicine, Baystate Medical Center and Division of Cardiovascular Medicine, University of Massachusetts-Baystate, Springfield, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) reduce adverse cardiovascular events when added to statins, but their effects on coronary plaque morphology remain inadequately defined. Methods: We searched PubMed via MEDLINE, Cochrane CENTRAL, Scopus, Web of Science for randomized controlled trials comparing the effects of PCSK9i plus statins versus statins alone on coronary atheroma morphology in patients with coronary artery disease, including total atheroma volume (TAV), percent atheroma volume (PAV), fibrous cap thickness (FCT), minimal lumen area (MLA), maximum lipid arc (MLArc), and lipid parameters. Random-effects models pooled mean differences (MDs). Results: Of 1,472 abstracts screened, eight randomized controlled trials ( Conclusions: The addition of PCSK9i to statin therapy improved coronary atheroma composition and morphology in patients with coronary artery disease.

Indexed as

Atherosclerotic plaque morphologyCoronary artery diseaseFibrous cap thicknessIntravascular ultrasoundOptical coherence tomographyPCSK9 inhibitorsPercent atheroma volume

Identifiers

PMID42827838
PMCPMC13632030

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.