Evidence map›Paper›PMID 42827833›Full record

ArticleChemical science2026

Stereosynthesis of stationary phase with precision defined separation selectivity.

Xiangyu Huang, Kaiyue Sun, Hanchen Cao, Zhuoheng Zhou, Jikai Chen, Qingshu Cai, Xiaofei Wang, Yanling Song, Teng-Xiang Huang, Ning Fang and 1 more

Abstract read
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Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiangyu HuangDepartment of Chemistry and the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, College of Chemistry and Chemical Engineering, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Xiamen University Xiamen 361005 China bozhang@xmu.edu.cn.
Kaiyue SunDepartment of Chemistry and the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, College of Chemistry and Chemical Engineering, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Xiamen University Xiamen 361005 China bozhang@xmu.edu.cn.
Hanchen CaoDepartment of Chemistry and the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, College of Chemistry and Chemical Engineering, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Xiamen University Xiamen 361005 China bozhang@xmu.edu.cn.
Zhuoheng ZhouBioanalytical Services, Department of Toxicology, WuXi AppTec (Suzhou) Co. Ltd Suzhou China.
Jikai ChenDepartment of Chemistry and the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, College of Chemistry and Chemical Engineering, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Xiamen University Xiamen 361005 China bozhang@xmu.edu.cn.
Qingshu CaiDepartment of Chemistry and the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, College of Chemistry and Chemical Engineering, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Xiamen University Xiamen 361005 China bozhang@xmu.edu.cn.
Xiaofei WangColumnScientific Inc. Xiamen 361102 China.
Yanling SongDepartment of Chemistry and the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, College of Chemistry and Chemical Engineering, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Xiamen University Xiamen 361005 China bozhang@xmu.edu.cn.
Teng-Xiang HuangDepartment of Chemistry and the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, College of Chemistry and Chemical Engineering, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Xiamen University Xiamen 361005 China bozhang@xmu.edu.cn.
Ning FangDepartment of Chemistry and the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, College of Chemistry and Chemical Engineering, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Xiamen University Xiamen 361005 China bozhang@xmu.edu.cn.
Bo ZhangDepartment of Chemistry and the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, College of Chemistry and Chemical Engineering, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Xiamen University Xiamen 361005 China bozhang@xmu.edu.cn.ORCID https://orcid.org/0000-0002-1538-839X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemical separation is based on molecules' differential interactions with a stationary phase and a mobile phase. To enable efficient thermodynamics and molecular kinetics, micrometer-size spheres with bonded chemistry have become the general choice for stationary phase materials. For half a century, the application of stationary-phase chemistry to microspheres has been a random, unordered and bulk process in the manufacture of chromatographic materials. Such a non-stereoresolving synthetic strategy results in the co-location of multiple functional groups, which share the same space, including those that are designed to function with different or opposite selectivities, such as hydrophobic and hydrophilic, cation exchange and anion exchange, and so on. The co-location of these functional ligands can cause severe interference with each other, leading to deviation from, or even having a detrimental effect on, the designed separation selectivity. This non-spatially resolved stationary-phase chemistry diminishes the effectiveness of mixed-mode separation and constrains the feasibility and freedom of multi-functionality assemblies when pursuing high separation performance. In this study, through microfluidic precision manufacturing, microspherical stationary phases were stereosynthesized with well-defined functional domains and the realization of quantitatively tunable chemical selectivity. With a classical mixed-mode stationary phase as a benchmark, it was found that the originally existing, but seriously constrained, chromatographic retentivity can now be unleashed by the spatially resolved arrangement of chemical functionality. The current study suggests that, as an unexplored structural parameter, the spatial distribution of stationary phase chemistry is an independent characteristic, which can enable the precision design and free tuning of thermodynamics, providing a new approach towards high-performance chromatography.

Identifiers

PMID42827833
PMCPMC13631962

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.