Evidence map›Paper›PMID 42827712›Full record

ArticleMaterials today. Bio2026

Biodegradable molybdenum intramedullary nails facilitate fracture repair through neutrophil-mediated immune response.

Chen Zhu, Yuchen He, Yili Zhao, Yingyi Huang, Chen Zhang, Jiannan Zhou, Huibin Liang, Haotian Qin, Zhonghan Fang, Danyang Liu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Chen ZhuSchool and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Medical University, Guangzhou, 510182, PR China.
Yuchen HeSchool and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Medical University, Guangzhou, 510182, PR China.
Yili ZhaoSchool and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Medical University, Guangzhou, 510182, PR China.
Yingyi HuangSchool and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Medical University, Guangzhou, 510182, PR China.
Chen ZhangDepartment of Bone and Joint Surgery, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, 518036, PR China.
Jiannan ZhouSchool and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Medical University, Guangzhou, 510182, PR China.
Huibin LiangSchool and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Medical University, Guangzhou, 510182, PR China.
Haotian QinDepartment of Bone and Joint Surgery, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, 518036, PR China.
Zhonghan FangSchool and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Medical University, Guangzhou, 510182, PR China.
Danyang LiuSchool and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Medical University, Guangzhou, 510182, PR China.
Jingtao DaiDepartment of Orthodontics, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, PR China.
Ping LiSchool and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Medical University, Guangzhou, 510182, PR China.
Junyu QianHand and Foot Surgery Department, Shenzhen Second People's Hospital (The First Hospital Affiliated to Shenzhen University), Shenzhen, 518000, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Molybdenum (Mo) has been considered as a promising biodegradable metal for fracture fixation owing to its favorable mechanical properties and controlled degradation behavior. Although existing studies have confirmed the osteoinductive potential of molybdenum-based materials, the biological mechanism through which molybdenum facilitates bone healing remains poorly elucidated. This study systematically evaluated the fracture repair performance of biodegradable Mo intramedullary nails in a rat femoral fracture model and further characterized the early peri-implant immune microenvironment using single-cell RNA sequencing in a day-3 femoral implantation model. Compared to the titanium (Ti)-based implant, the Mo-based implant significantly accelerated fracture healing, as evidenced by improved radiographic and micro-CT outcomes, enhanced matrix deposition, and mineralized bone formation, and increased expression of osteogenesis-related markers. Single-cell transcriptomic analysis revealed that the Mo-based metal induced a distinct immune landscape characterized by enrichment of neutrophils and macrophages and enhanced crosstalk between these two myeloid populations. Among the identified subsets,

Indexed as

Biodegradable molybdenumBone fractureBone repairMacrophageNeutrophilSingle-cell sequencing

Identifiers

PMID42827712
PMCPMC13631628

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.