ArticleKidney medicine2026
Prolonged Ovarian Hyperstimulation Syndrome in a Patient With Advanced Kidney Disease.
Article in Kidney medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Assisted reproductive technologies such as in vitro fertilization (IVF) have expanded fertility options for women with chronic kidney disease (CKD), a population with a high prevalence of infertility. Patients with CKD are at increased risk of complications from ovarian stimulation. Ovarian hyperstimulation syndrome (OHSS) is a potentially serious iatrogenic complication marked by increased vascular permeability, third-space fluid shifts, and increased risk of systemic complications such as acute kidney injury. We present a case of prolonged OHSS complicated by acute kidney injury, hyperkalemia and proteinuria in a patient with baseline stage 4 CKD who underwent IVF. Despite use of gonadotropin-releasing hormone antagonist protocol and a prophylactic dopamine agonist, the patient developed early-onset OHSS with ascites, elevated creatinine, hyperkalemia, and proteinuria. This case highlights the increased susceptibility of advanced patients with CKD to moderate-severe and prolonged OHSS, underscoring the need for individualized ovarian stimulation protocols, close nephrology-reproductive endocrinology collaboration, and vigilant monitoring of kidney function during and after IVF treatments.
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