ArticleFrontiers in medicine2026
Predictive value of pre-procedural QTc interval for in-hospital major adverse cardiovascular events following primary percutaneous coronary intervention in acute myocardial infarction.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Background: The relationship between pre-procedural corrected QT (QTc) interval and in-hospital major adverse cardiovascular events (MACE) following primary percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) remains incompletely understood. This study evaluated the predictive value of pre-procedural QTc for in-hospital MACE. Methods: This single-center retrospective cohort study consecutively enrolled AMI patients undergoing primary PCI. QTc intervals were manually measured from pre-procedural 12-lead electrocardiograms using the Bazett formula, with a prespecified sensitivity analysis using the Fridericia formula. Missing data sensitivity analyses (complete-case BNP model and multiple imputation, m = 20) confirmed that BNP adjustment did not alter the QTc effect. No formal sample size calculation was performed; findings are exploratory. The primary endpoint was in-hospital MACE (composite of ventricular arrhythmias, cardiogenic shock, acute heart failure, and bleeding complications). Logistic regression and receiver operating characteristic (ROC) analyses were performed.Among 123 patients (mean age 55.3 ± 11.9 years; 91.1% male), 53 (43.1%) experienced MACE. Prolonged QTc (>440 ms) was associated with MACE in univariate analysis (OR = 3.01, 95% CI: 1.41-6.39, Conclusions: Pre-procedural QTc prolongation is associated with in-hospital MACE but is not an independent predictor after adjustment for conventional risk factors, with limited incremental value (
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