Observational studyFrontiers in neurology2026
Ultrasound-guided continuous radiofrequency of the C2 dorsal root ganglion for menstrually related migraine: a comparative clinical study.
Observational study in Frontiers in neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Background: Menstrually related migraine (MRM) is a common migraine subtype in women and is often accompanied by gastrointestinal symptoms, anxiety, and depression, leading to substantial functional impairment. Conventional pharmacological treatments show limited efficacy in improving long-term symptoms and quality of life. This study aimed to compare the clinical effectiveness of ultrasound-guided continuous radiofrequency (CRF) of the C2 dorsal root ganglion with conventional zolmitriptan therapy in patients with MRM. Methods: This retrospective comparative observational study (using prospectively collected clinical data) included 69 patients with MRM treated between January and December 2024. Patients were assigned to a conventional medication group receiving oral zolmitriptan (Group C, Results: Both groups showed significant improvements in headache symptoms and functional outcomes compared with baseline ( Conclusion: In this retrospective comparative observational study, ultrasound-guided continuous radiofrequency of the C2 dorsal root ganglion was associated with greater improvements in headache symptoms, psychological status, and functional disability compared with oral zolmitriptan therapy in patients with MRM, with a favorable safety profile. These findings should be interpreted with caution given the different treatment modalities and study design limitations. Trial registration: This study was registered in the Chinese Clinical Trial Registry (ChiCTR2500095771).
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