Evidence map›Paper›PMID 42827633›Full record

ArticleJBMR plus2026

Involvement of reduced ENPP1 function in the pathogenesis of ossification of the posterior longitudinal ligament.

Soichiro Kimura, Koichiro Furukawa, Koki Irie, Natsuho Adachi, Yoshitomo Hoshino, Naoko Hidaka, Hajime Kato, Junya Miyahara, Yasushi Oshima, Toru Doi and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JBMR plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Soichiro KimuraDivision of Nephrology and Endocrinology, The University of Tokyo Hospital, Bunkyo, Tokyo 113-8655, Japan.ORCID https://orcid.org/0000-0003-2385-428X
Koichiro FurukawaDivision of Nephrology and Endocrinology, The University of Tokyo Hospital, Bunkyo, Tokyo 113-8655, Japan.ORCID https://orcid.org/0009-0008-7292-5738
Koki IrieDivision of Nephrology and Endocrinology, The University of Tokyo Hospital, Bunkyo, Tokyo 113-8655, Japan.ORCID https://orcid.org/0009-0007-1638-7202
Natsuho AdachiOsteoporosis Center, The University of Tokyo Hospital, Bunkyo, Tokyo 113-8655, Japan.ORCID https://orcid.org/0009-0008-3486-3070
Yoshitomo HoshinoDivision of Nephrology and Endocrinology, The University of Tokyo Hospital, Bunkyo, Tokyo 113-8655, Japan.ORCID https://orcid.org/0000-0002-5226-2227
Naoko HidakaDivision of Nephrology and Endocrinology, The University of Tokyo Hospital, Bunkyo, Tokyo 113-8655, Japan.ORCID https://orcid.org/0000-0002-5450-2247
Hajime KatoDivision of Nephrology and Endocrinology, The University of Tokyo Hospital, Bunkyo, Tokyo 113-8655, Japan.ORCID https://orcid.org/0000-0001-9178-7846
Junya MiyaharaDepartment of Orthopaedic Surgery, The University of Tokyo Hospital, Bunkyo, Tokyo 113-8655, Japan.ORCID https://orcid.org/0000-0002-6369-5829
Yasushi OshimaDepartment of Orthopaedic Surgery, The University of Tokyo Hospital, Bunkyo, Tokyo 113-8655, Japan.ORCID https://orcid.org/0000-0003-4696-1846
Toru DoiDepartment of Orthopaedic Surgery, Tokyo Women's Medical University, Shinjuku, Tokyo 162-8666, Japan.ORCID https://orcid.org/0000-0001-8833-2437
Masaomi NangakuDivision of Nephrology and Endocrinology, The University of Tokyo Hospital, Bunkyo, Tokyo 113-8655, Japan.ORCID https://orcid.org/0000-0001-7401-2934
Noriko MakitaDivision of Nephrology and Endocrinology, The University of Tokyo Hospital, Bunkyo, Tokyo 113-8655, Japan.ORCID https://orcid.org/0000-0002-5722-115X
Sakae TanakaDepartment of Orthopaedic Surgery, The University of Tokyo Hospital, Bunkyo, Tokyo 113-8655, Japan.ORCID https://orcid.org/0000-0001-9210-9414
Taku SaitoOsteoporosis Center, The University of Tokyo Hospital, Bunkyo, Tokyo 113-8655, Japan.ORCID https://orcid.org/0000-0003-4911-3930
Nobuaki ItoOsteoporosis Center, The University of Tokyo Hospital, Bunkyo, Tokyo 113-8655, Japan.ORCID https://orcid.org/0000-0002-4071-5372

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ossification of the posterior longitudinal ligament (OPLL) is an ectopic ossification disorder with incompletely understood pathophysiology. In a previously reported 50-patient OPLL cohort, ectonucleotide pyrophosphatase/phosphodiesterase 1 (

Indexed as

diffuse idiopathic skeletal hyperostosisectopic ossificationENPP1enthesopathyossification of the posterior longitudinal ligamentpyrophosphate

Identifiers

PMID42827633
PMCPMC13630564

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.