ReviewFrontiers in bioengineering and biotechnology2026
Autologous protein solution and 3D-Printed technologies as potential adjuncts to arthroscopic elbow release: a narrative review and conceptual framework.
Review in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Post-traumatic and degenerative elbow stiffness is a major cause of upper-limb disability, as relatively small losses of elbow and forearm motion can significantly impair activities of daily living and work capacity. Arthroscopic elbow release has evolved as a joint-preserving alternative to open arthrolysis in selected cases. Multiple series have demonstrated meaningful gains in flexion including extension arc and forearm rotation, high patient satisfaction, and low complication rates. However, residual pain, recurrent stiffness, and progressive osteoarthritic change remain problematic in a subset of patients. In parallel, autologous protein solution (APS), an autologous blood-derived product enriched in anti-inflammatory cytokines and anabolic factors, has shown promising preclinical effects in modulating IL-1/TNF-driven cartilage catabolism. Clinical studies in knee osteoarthritis report that single intra-articular APS injections are safe and can improve pain and function in selected patients with mild-to-moderate disease, although recent randomized data are mixed and benefits appear attenuated in advanced disease. Importantly, evidence for APS in upper-limb joints, particularly the elbow, remains essentially unavailable. Three-dimensional (3D) printed digital orthopedics offers expanded options for preoperative planning and personalized bracing in complex elbow conditions, though high-quality clinical trials are lacking. This review synthesizes current evidence on APS in osteoarthritis, arthroscopic elbow release, and 3D-printed digital orthopedics, proposing a hypothetical joint-preserving pathway where arthroscopic release restores mechanics, APS provides biological modulation in selected patients, and 3D-printed devices personalize planning and postoperative rehabilitation. We emphasize that this integrated approach is currently based on indirect evidence and requires formal clinical validation before adoption into practice.
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