ArticleFrontiers in neurology2026
A predictive model of serum calcium and 25-hydroxyvitamin D for recurrence of benign paroxysmal positional vertigo in the elderly: a single-center follow-up cohort study.
Article in Frontiers in neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: To investigate the predictive value of serum calcium and 25-hydroxyvitamin D (25-OH-VD) on recurrence after canalith repositioning procedure (CRP) in elderly patients with benign paroxysmal positional vertigo (BPPV), and to establish a quantitative prediction model. Methods: A single-center follow-up cohort study was conducted involving 286 elderly BPPV patients (age≥60 years) treated with CRP from January 2020 to June 2025. Patients were followed for 1 year and divided into a non-recurrence group ( Results: Serum calcium (1.94 ± 0.47 mmol/L) and 25-OH-VD (15.34 ± 3.45 ng/mL) levels were significantly lower in the recurrence group compared to the non-recurrence group (2.35 ± 0.56 mmol/L, 18.44 ± 3.74 ng/mL) and controls (2.68 ± 0.48 mmol/L, 23.61 ± 3.92 ng/mL; all Conclusion: Serum calcium and reduced 25-OH-VD are independent predictive factors for post-CRP recurrence in elderly BPPV patients, and their combination improves predictive efficacy. The predictive model provides a quantitative basis for early identification of high-risk patients. However, due to its relatively low sensitivity, the model should be used as an adjunctive tool rather than a standalone test in clinical practice. These findings require further external validation in multi-center studies, and interventional effects of calcium and vitamin D supplementation should be confirmed by randomized controlled trials.
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