Evidence map›Paper›PMID 42827554›Full record

ArticleFrontiers in oncology2026

The deubiquitinating enzyme UCHL3 promotes bladder cancer progression and glycolysis through enhancing PKM2 protein stability.

Gengsheng Shi, Yanyan Wu, Yingying Wang, Suyu Wang, Wan Xiang, Wenqin Yin, Ruirui Li

Abstract read
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Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gengsheng Shi *Department of Clinical and Public Health, Jiangsu College of Nursing, Huaian, Jiangsu, China.
Yanyan Wu *Department of Endocrinology, Taizhou Second People's Hospital Affiliated to Yangzhou University, Taizhou, Jiangsu, China.
Yingying Wang *Endoscopy Center, Jiangsu Province (Suqian) Hospital, Suqian, Jiangsu, China.
Suyu WangDepartment of Clinical and Public Health, Jiangsu College of Nursing, Huaian, Jiangsu, China.
Wan XiangDepartment of Biological Repositories, Human Genetic Resources Preservation Center of Hubei Province, Hubei Key Laboratory of Urological Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China.
Wenqin YinDepartment of Clinical and Public Health, Jiangsu College of Nursing, Huaian, Jiangsu, China.
Ruirui LiMedical Department, Jiangsu Province (Suqian) Hospital, Suqian, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pyruvate kinase M2 (PKM2) is a critical rate-limiting enzyme in glycolysis and is frequently upregulated in bladder cancer (BCa), contributing to the Warburg effect and tumor progression. However, the mechanism supporting abnormal PKM2 stabilization via deubiquitination in BCa remains to be characterized. Here, we identified ubiquitin C-terminal hydrolase L3 (UCHL3) as a bona fide deubiquitylase of PKM2 in BCa. UCHL3 stabilized PKM2 in a deubiquitylation activity-dependent manner. UCHL3 depletion significantly decreased PKM2 protein levels, suppressed glycolytic activity, and inhibited BCa cell proliferation, colony formation, migration

Indexed as

bladder cancerglycolysisPKM2ubiquitinationUCHL3

Identifiers

PMID42827554
PMCPMC13630518

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.