ArticleNature health2026
Maternal metabolomic signatures for risk of preterm and early term birth in African American women.
Youran Tan, Donghai Liang, Stephanie M Eick, Mengyuan Ren, Douglas I Walker, Xin Hu, Zhenjiang Li, Kaitlin R Taibl, Elizabeth Corwin, Cherie C Hill and 2 more
Abstract read
In one paragraphArticle in Nature health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
12 authors.
Youran Tan *Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA USA.ORCID 0000-0002-9955-8324 Donghai Liang *Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA USA.ORCID 0000-0001-7311-2298 Stephanie M EickGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA USA.
Mengyuan RenGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA USA.ORCID 0000-0003-3819-4181 Douglas I WalkerGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA USA.
Xin HuGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA USA.
Zhenjiang LiKeck School of Medicine of University of Southern California, Los Angeles, CA USA.
Kaitlin R TaiblGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA USA.
Elizabeth CorwinSchool of Nursing, Columbia University, New York City, NY USA.
Cherie C HillDepartment of Gynecology and Obstetrics, School of Medicine, Emory University, Atlanta, GA USA.ORCID 0000-0001-6660-8180 Anne L DunlopDepartment of Gynecology and Obstetrics, School of Medicine, Emory University, Atlanta, GA USA.ORCID 0000-0002-5092-8136 Funding
Pilot Project ProgramP30ES019776 · NIEHS · EMORY UNIVERSITY · PI William Michael Caudle · 2013 to 2026
$22.6MThe Impact of the Intrauterine and Early Childhood Environments on Neurocognitive and Metabolic Development in African American Youth: Focus on the Gut-Brain AxisUH3OD023318 · OD · EMORY UNIVERSITY · PI PATRICIA A BRENNAN, ANNE Lang DUNLOP · 2018 to 2026
$9.0MMaternal Stress and the Gut-Brain Axis in African American InfantsR01MD009746 · NIMHD · EMORY UNIVERSITY · PI BRENNAN, PATRICIA A, CORWIN, ELIZABETH JEANNE · 2015 to 2019
$3.6MBiobehavioral Determinants of the Microbiome and Preterm Birth in Black WomenR01NR014800 · NINR · EMORY UNIVERSITY · PI CORWIN, ELIZABETH JEANNE, DUNLOP, ANNE LANG · 2013 to 2017
$2.8MMaintenance and Enhancement of the Atlanta African American Maternal-Child Cohort: Exposome Profiling via High-resolution Metabolomics and Integration of Microbiome-Metabolome-Epigenome DataR24ES029490 · NIEHS · EMORY UNIVERSITY · PI ANNE Lang DUNLOP, Dean Paul Jones · 2018 to 2026
$2.4MThe Omics and Mixtures Integration on Traffic exposure and Preterm Birth (OMIT-PTB) StudyR01ES035738 · NIEHS · EMORY UNIVERSITY · PI Donghai Liang · 2024 to 2026
$2.0MEpigenetic and Biobehavioral Determinants of Preterm Birth in Black WomenR01MD009064 · NIMHD · EMORY UNIVERSITY · PI DUNLOP, ANNE LANG, SMITH, ALICIA K · 2014 to 2018
$1.9MTraffic Exposure, Maternal Metabolome and Birth Outcomes Study (TEMMBO Study)R21ES032117 · NIEHS · EMORY UNIVERSITY · PI LIANG, DONGHAI · 2021 to 2022
$420kNIEHS NIH HHS P30 ES019776NIEHS NIH HHS R01 ES035738NIEHS NIH HHS R21 ES032117NIEHS NIH HHS R24 ES029490NIH HHS UH3 OD023318NIMHD NIH HHS R01 MD009064NIMHD NIH HHS R01 MD009746NINR NIH HHS R01 NR014800
6 · The paper itselfAbstract
Metabolic signals identifying pregnancies at risk for preterm birth (<37 weeks) and early term birth (37-38 weeks) remain limited. Here we used high-resolution metabolomics to characterize metabolic features associated with spontaneous and medically indicated early birth. We conducted metabolome-wide association studies among 279 (discovery) and 251 (internal validation) pregnant women from the Atlanta African American Maternal-Child Cohort (2014-2018), with serum collected in early (8-14 weeks) and later (24-30 weeks) pregnancy. Distinct metabolic profiles differentiated spontaneous and medically indicated preterm birth and early term birth across pregnancy windows. Perturbations in amino acid pathways, including arginine, proline, aspartate, glutamate, methionine and cysteine metabolism, were observed. Valine, leucine and tyrosine were inversely associated with spontaneous early birth, while acylcarnitines and aldosterone were associated with medically indicated early birth. Thirteen metabolites were validated, supporting their potential as markers of pregnancies at elevated risk.
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BiomarkersDiseasesHigh-throughput screening
Identifiers
PMID42827540
PMCPMC13630546
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