Evidence map›Paper›PMID 42827443›Full record

ArticleFrontiers in medicine2026

Isolated gastric Kaposi sarcoma following allogeneic 2 hematopoietic stem cell transplantation: A Case Report and Literature Review.

Aysheh Obeidat, Leen Al-Kraimeen, Fareed Barakat, Zaid Abdel Rahman

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Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Aysheh ObeidatDepartment of Internal Medicine, King Hussein Cancer Center, Amman, Jordan.
Leen Al-KraimeenDepartment of Internal Medicine, King Hussein Cancer Center, Amman, Jordan.
Fareed BarakatDepartment of Pathology and Laboratory Medicine, King Hussein Cancer Center, Amman, Jordan.
Zaid Abdel RahmanDepartment of Internal Medicine, King Hussein Cancer Center School of Medicine, University of Jordan, Amman, Jordan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Kaposi sarcoma (KS) is a rare complication after hematopoietic stem cell transplantation (HSCT). Case presentation: We report a 20-year-old male with severe aplastic anemia who underwent HLA-matched sibling allogeneic HSCT. Three months later, he developed abdominal pain, nausea, and diarrhea suspected to represent gastrointestinal graft-versus-host disease. Endoscopic evaluation revealed multiple ulcerated gastric nodules, and histopathologic examination demonstrated spindle-cell proliferation with positive HHV-8 and CD34 immunostaining, confirming KS. Staging with computed tomography of the chest, abdomen, and pelvis showed no additional visceral involvement, and examination of the skin and mucous membranes showed no evidence of cutaneous or mucosal disease. Immunosuppression was gradually tapered. However, the patient developed rapidly progressive respiratory failure with positive blood HHV-8 polymerase chain reaction. HHV-8 pneumonitis was suspected but could not be confirmed, and the patient died despite supportive management. Results: A literature review identified 20 reported cases of KS following HSCT. Most cases occurred within the first year after transplantation while on immunosuppression. Cutaneous involvement was the predominant presentation, whereas isolated visceral disease was exceptionally uncommon. Reduction or discontinuation of immunosuppression was the most frequent treatment option, while visceral involvement was associated with poorer outcomes. Conclusion: To our knowledge, no previously published case of isolated gastric KS following allogeneic HSCT was identified in our literature search. It highlights the importance of considering KS in the differential diagnosis of gastrointestinal symptoms after HSCT and supports early endoscopic biopsy with HHV-8 immunohistochemical evaluation to facilitate timely diagnosis.

Indexed as

case reportHHV-8HSCTkaposi sarcomapneumonitis

Identifiers

PMID42827443
PMCPMC13630594

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