ArticleFrontiers in cardiovascular medicine2026
Ischemic heart disease mortality trends and disparities in US adults from 1999 to 2023: a CDC WONDER analysis.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Ischemic heart disease (IHD) remains a leading cause of mortality in the United States, yet it remains unclear whether postpandemic recovery patterns differ across population subgroups. Methods: Using CDC WONDER data (1999-2023), we analyzed IHD deaths among US adults aged ≥25 years. Age-adjusted mortality rates (AAMRs) were stratified by sex, race/ethnicity, urbanization, and region; crude mortality rates (CMRs) by age. Urban-rural analyses were restricted to 1999-2020. Joinpoint regression estimated temporal trends, and tests of parallelism assessed between-group differences. Results: Among 10,200,362 IHD deaths, overall AAMRs declined from 300.8 to 127.07 per 100,000 (average annual percent change, AAPC = -3.51; Conclusions: Despite sustained IHD mortality declines, significant disparities persist across demographic and geographic subgroups, supporting targeted prevention for high-risk populations.
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