Evidence map›Paper›PMID 42827210›Full record

ArticleForensic science, medicine, and pathology2026

An autopsy case of diphenhydramine overdose with drug concentration data from multiple samples sites.

Sella Takei, Mostofa Jamal, Tadayoshi Yamashita, Etsuko Tanaka, Sachiko Kawahara, Hiroko Abe, Takehiko Murase, Hiroshi Kinoshita

Abstract read
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In one paragraph

Article in Forensic science, medicine, and pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sella TakeiDepartment of Forensic Medicine, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki, Kita, 761-0793, Kagawa, Japan. takei.sella@kagawa-u.ac.jp.ORCID http://orcid.org/0000-0002-6492-1453
Mostofa JamalDepartment of Forensic Medicine, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki, Kita, 761-0793, Kagawa, Japan.
Tadayoshi YamashitaDepartment of Forensic Medicine, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki, Kita, 761-0793, Kagawa, Japan.
Etsuko TanakaDepartment of Forensic Medicine, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki, Kita, 761-0793, Kagawa, Japan.
Sachiko KawaharaDepartment of Forensic Medicine, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki, Kita, 761-0793, Kagawa, Japan.
Hiroko AbeDepartment of Forensic Medicine, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki, Kita, 761-0793, Kagawa, Japan.
Takehiko MuraseDepartment of Forensic Medicine, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki, Kita, 761-0793, Kagawa, Japan.
Hiroshi KinoshitaDepartment of Forensic Medicine, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki, Kita, 761-0793, Kagawa, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diphenhydramine (DPH) is a commonly used over-the-counter drug. However, its widespread availability may contribute to severe and potentially fatal overdoses. DPH concentrations measured at multiple sampling sites have rarely been reported in fatal overdoses. This case report describes a fatal DPH overdose in a young woman whose blood DPH concentrations at multiple sampling sites exceeded the lethal range. DPH concentrations in blood and stomach contents enabled estimation of the amount of drug ingested, which was consistent with the investigative findings. Furthermore, the high DPH concentration in portal venous blood suggested that death occurred during the drug absorption phase. In fatal drug intoxication, measurement of drug concentrations at multiple sampling sites can provide complementary information for evaluating drug pharmacokinetics and the circumstances surrounding death.

Indexed as

DiphenhydramineForensic pathologyForensic toxicologyLC-MS/MSOverdoseOver-the-counter drug

Identifiers

PMID42827210

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.