Evidence map›Paper›PMID 42827108›Full record

ArticleExperimental & molecular medicine2026

Maresin1 improves cardiac dysfunction via LGR6 in heatstroke.

Ya-Ting Jiang, Chen-Xi Shen, Suwas Bhandari, Li-Ran Su, Fang-Jing Ni, Shuang-Shuang Li, Bo Feng, Wen-Yan Zhang, Lin-Feng Liu, Jun Luo and 6 more

Abstract read
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Article in Experimental & molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

16 authors.

Ya-Ting JiangDepartment of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Key Laboratory of Pediatric Anesthesiology, Ministry of Education, Wenzhou Medical University, Key Laboratory of Anesthesiology of Zhejiang Province, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Chen-Xi ShenDepartment of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Key Laboratory of Pediatric Anesthesiology, Ministry of Education, Wenzhou Medical University, Key Laboratory of Anesthesiology of Zhejiang Province, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Suwas BhandariDepartment of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Key Laboratory of Pediatric Anesthesiology, Ministry of Education, Wenzhou Medical University, Key Laboratory of Anesthesiology of Zhejiang Province, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Li-Ran SuDepartment of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Key Laboratory of Pediatric Anesthesiology, Ministry of Education, Wenzhou Medical University, Key Laboratory of Anesthesiology of Zhejiang Province, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Fang-Jing NiDepartment of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Key Laboratory of Pediatric Anesthesiology, Ministry of Education, Wenzhou Medical University, Key Laboratory of Anesthesiology of Zhejiang Province, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Shuang-Shuang LiDepartment of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Key Laboratory of Pediatric Anesthesiology, Ministry of Education, Wenzhou Medical University, Key Laboratory of Anesthesiology of Zhejiang Province, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Bo FengDepartment of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Key Laboratory of Pediatric Anesthesiology, Ministry of Education, Wenzhou Medical University, Key Laboratory of Anesthesiology of Zhejiang Province, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Wen-Yan ZhangDepartment of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Key Laboratory of Pediatric Anesthesiology, Ministry of Education, Wenzhou Medical University, Key Laboratory of Anesthesiology of Zhejiang Province, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Lin-Feng LiuDepartment of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Key Laboratory of Pediatric Anesthesiology, Ministry of Education, Wenzhou Medical University, Key Laboratory of Anesthesiology of Zhejiang Province, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Jun LuoDepartment of Pharmacy, Taizhou Women and Children's Hospital of Wenzhou Medical University, Taizhou, Zhejiang, China.
Xiao-Dong PanDepartment of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Key Laboratory of Pediatric Anesthesiology, Ministry of Education, Wenzhou Medical University, Key Laboratory of Anesthesiology of Zhejiang Province, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Yu-Jie ZhouDepartment of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Key Laboratory of Pediatric Anesthesiology, Ministry of Education, Wenzhou Medical University, Key Laboratory of Anesthesiology of Zhejiang Province, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Hui LiDepartment of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Key Laboratory of Pediatric Anesthesiology, Ministry of Education, Wenzhou Medical University, Key Laboratory of Anesthesiology of Zhejiang Province, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Yu-Qiang GongDepartment of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Key Laboratory of Pediatric Anesthesiology, Ministry of Education, Wenzhou Medical University, Key Laboratory of Anesthesiology of Zhejiang Province, Wenzhou Medical University, Wenzhou, Zhejiang, China. gyq12120@163.com.
Sheng-Wei JinDepartment of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Key Laboratory of Pediatric Anesthesiology, Ministry of Education, Wenzhou Medical University, Key Laboratory of Anesthesiology of Zhejiang Province, Wenzhou Medical University, Wenzhou, Zhejiang, China. jsw@wmu.edu.cn.
Yu HaoDepartment of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Key Laboratory of Pediatric Anesthesiology, Ministry of Education, Wenzhou Medical University, Key Laboratory of Anesthesiology of Zhejiang Province, Wenzhou Medical University, Wenzhou, Zhejiang, China. haoyu@wmu.edu.cn.ORCID http://orcid.org/0000-0002-8351-1206

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82300072Natural Science Foundation of Zhejiang Province (Zhejiang Provincial Natural Science Foundation) LQ23H010003Natural Science Foundation of Zhejiang Province (Zhejiang Provincial Natural Science Foundation) LY24H150003
6 · The paper itself

Abstract

Heatstroke is a severe and life-threatening condition that can lead to cardiac dysfunction and poses a high risk of mortality. Maresin1, an endogenous lipid mediator, reportedly promotes inflammation resolution in various inflammatory diseases. However, its cardioprotective role during heatstroke has not been thoroughly investigated. In this study, we used ultra-performance liquid chromatography-tandem mass spectrometry to measure the levels of Maresin1 in the plasma and cardiac tissues of mice exposed to heatstroke. Our results indicated a notable decrease in Maresin1 levels under heatstroke conditions. In addition, the levels of leucine-rich repeat-containing G-protein-coupled receptor 6 (LGR6), a receptor for Maresin1, were increased in mice exposed to heatstroke. Exogenously administered Maresin1 significantly improved survival rates and alleviated the symptoms of heatstroke. Conversely, in Lgr6-knockout mice, the symptoms worsened, and the mortality rate increased. Transcriptomic analysis of the cardiac tissue and in vitro experiments have confirmed that Maresin1 exerts cardioprotective effects by inhibiting oxidative stress and promoting ATP synthesis through the upregulation of peroxisome proliferator-activated receptor-γ coactivator 1α (PGC1α) mediated via LGR6. Nuclear respiratory factor 1 (NRF1) and nuclear respiratory factor 2 (NRF2) were also increased downstream, likely as a secondary response associated with improved mitochondrial biogenesis rather than direct transcriptional regulation by LGR6. Our findings indicate that the Maresin1-LGR6 axis serves a cardioprotective role in heatstroke and is a potential therapeutic target for heatstroke-induced cardiac dysfunction.

Identifiers

PMID42827108

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