Evidence map›Paper›PMID 42827095›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2026

Association of atropine use during neonatal intubation with cardiac arrest, severe bradycardia, and other adverse events: a report from NEAR4NEOS.

Taylor Sawyer, Michael Narvey, Michelle D Tyler, Ayman Abou Mehrem, Sabine Iben, Cassandra DeMartino, David Tingay, Kate Hodgson, Jae Kim, Heidi Herrick and 21 more

Abstract read
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In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Taylor SawyerDepartment of Pediatrics, Division of Neonatology, University of Washington School of Medicine, Seattle, WA, USA. tlsawyer@uw.edu.ORCID http://orcid.org/0000-0002-3908-8957
Michael NarveyDepartment of Pediatrics, University of Manitoba, Winnipeg, MB, Canada.ORCID http://orcid.org/0000-0002-5863-4212
Michelle D TylerDivision of Neonatology, Department of Pediatrics, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
Ayman Abou MehremDepartment of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.ORCID http://orcid.org/0000-0003-3805-949X
Sabine IbenDivision of Neonatology, Cleveland Clinic Children's, Cleveland, OH, USA.ORCID http://orcid.org/0000-0002-1145-2956
Cassandra DeMartinoDepartment of Pediatrics, Division of Neonatology, Yale University School of Medicine New Haven, CT, New Haven, USA.
David TingayDepartment of Paediatrics, University of Melbourne, Parkville, VIC, Australia.
Kate HodgsonDepartment of Obstetrics, Gynaecology and Newborn Health, University of Melbourne, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0002-2908-1049
Jae KimDepartment of Pediatrics, Division of Neonatology, University of California, San Diego, CA, USA.ORCID http://orcid.org/0000-0001-6321-2594
Heidi HerrickDepartment of Pediatrics, Division of Neonatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-0723-6898
Jennifer UnrauDepartment of Pediatrics, Division of Neonatal Critical Care, Alberta Children's Hospital, Calgary, AB, Canada.
Mihai Puia-DumitrescuDepartment of Pediatrics, Division of Neonatology, University of Washington School of Medicine, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-7847-5204
Rebecca ShayDepartment of Pediatrics, Division of Neonatology, University of Colorado, Aurora, CO, USA.ORCID http://orcid.org/0000-0002-7181-2757
Stephen DeMeoDepartment of Neonatology, WakeMed Health & Hospitals, Raleigh, NC, USA.
Michael-Andrew AssaadCentre Hospitalier Universitaire Sainte-Justine, Université de Montréal, Montreal, QC, Canada.ORCID http://orcid.org/0000-0001-8906-8359
Joyce O'SheaDepartment of Neonatology, Royal Hospital for Children, Glasgow, UK.
Ivana BrajkovicDepartment of Pediatrics, Division of Neonatology, University of Washington School of Medicine, Seattle, WA, USA.
Bin Huey QuekDepartment of Neonatology, KK Women's and Children's Hospital, Singapore, Singapore.ORCID http://orcid.org/0000-0001-8891-5464
Kristen GlassDepartment of Pediatrics, Division of Neonatology, Penn State College of Medicine, Hershey, PA, USA.ORCID http://orcid.org/0000-0003-2682-4019
Michael WagnerDivision of Neonatology, Pediatric Intensive Care and Neuropediatrics, Department of Pediatrics, Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria.
Katharina BiblDepartment of Pediatrics, Division of Neonatology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Jennifer RumpelDepartment of Pediatrics, Division of Neonatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-5883-218X
Devin McKissicDepartment of Pediatrics, Division of Neonatology, University of Washington School of Medicine, Seattle, WA, USA.ORCID http://orcid.org/0009-0003-2160-7055
Nicole PouppirtDepartment of Respiratory Therapy, Children's Hospital of Philadelphia, PA, Philadelphia, USA.ORCID http://orcid.org/0000-0003-3779-285X
Paul WildenhainDepartment of Pediatrics, Division of Neonatal Critical Care, Alberta Children's Hospital, Calgary, AB, Canada.
Natalie NapolitanoDepartment of Biostatistics, Epidemiology and Informatics in the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Justine ShultsDepartment of Anesthesiology, Critical Care Medicine, and Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Joseph ReiterDepartment of Pediatrics, Division of Neonatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-3806-4192
Elizabeth E Foglia *Department of Pediatrics, Division of Neonatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-9925-5219
Akira Nishisaki *Department of Anesthesiology, Critical Care Medicine, and Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
National Emergency Airway Registry for Neonates (NEAR4NEOS) investigators

Funding

Optimizing Tracheal Intubation Outcomes and Neonatal Safety (OPTION SAFE)R01HD106996 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI Elizabeth Foglia · 2022 to 2026
$3.6M
Improving safety and quality of tracheal intubations in neonatal ICUsR21HD089151 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI NISHISAKI, AKIRA · 2017 to 2018
$470k
U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) R01HD106996U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) R21HD089151
6 · The paper itself

Abstract

objectiveEvaluate the association between atropine use during neonatal tracheal intubation (TI) and procedural safety and success. STUDY

designRetrospective multicenter cohort study of neonatal TIs in the NEAR4NEOS registry (2014-2023). Multivariable logistic regression assessed associations between atropine use and cardiac arrest (primary outcome), along with safety and procedural outcomes, adjusting for confounders.

resultsAtropine was used in 8189 of 13,085 TIs (62.6%). It was not associated with reduced odds of cardiac arrest (aOR 0.52, 95% CI 0.25-1.09). Atropine use was associated with lower odds of severe bradycardia (aOR 0.33, 95% CI 0.26-0.41), but higher odds of oxygen desaturation (aOR 1.35, 95% CI 1.22-1.49) and lower first-attempt success (aOR 0.76, 95% CI 0.69-0.85).

conclusionAtropine use during neonatal TI was not associated with reduced cardiac arrest. Although it reduced severe bradycardia, it was associated with increased desaturation and lower first-attempt success, warranting further study.

Identifiers

PMID42827095

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.