ArticleMedicine2026
Exploring the independent factors influencing prolonged QTc intervals in patients with acute-on-chronic liver failure caused by hepatitis B.
Article in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
Prolonged QTc interval is a common electrophysiological abnormality in patients with chronic liver disease, but limited evidence exists regarding its occurrence in acute-on-chronic liver failure (ACLF), particularly in hepatitis B virus-related ACLF (HBV-ACLF). Given the rapid progression, high mortality, and severe complications associated with ACLF, understanding cardiac electrophysiological changes is clinically important. This study aimed to determine the incidence of QTc prolongation in patients with HBV-ACLF and to identify independent factors associated with QTc abnormalities. A retrospective study was conducted on 206 consecutive patients with HBV-ACLF admitted between January 2016 and December 2023. Heart rate and QT interval data were obtained from 12-lead electrocardiograms performed at admission. QTc was calculated using Bazett's formula. Patients were categorized into prolonged and non-prolonged QTc groups using a cutoff of 440 ms. Demographic, clinical, and laboratory variables were compared, and significant factors (P < .05) were entered into multivariate logistic regression to determine independent predictors. Of the 206 patients included, 68 (33%) exhibited prolonged QTc intervals. Univariate analysis revealed significant differences in red blood cell count (RBC), total cholesterol (CHOL), creatinine (CRE), potassium (K), fibrinogen (FIB), ascites, HBV-DNA level, and Child-Pugh classification (all P < .05). Multivariate logistic regression identified K, CRE, HBV-DNA, and ascites as independent predictors of QTc prolongation (P < .05 for all). Approximately one-third of patients with HBV-ACLF demonstrated prolonged QTc intervals. Electrolyte imbalance, renal dysfunction, viral replication activity, and ascites were independently associated with QTc prolongation. Routine QTc monitoring may provide a simple and noninvasive tool for early identification of patients at increased risk of cardiac complications.
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