Evidence map›Paper›PMID 42826325›Full record

ArticleMedicine2026

Primary pulmonary mucosa-associated lymphoid tissue lymphoma presenting as a right hilar mass: A case report.

Liyuan Fu, Taipeng Zeng, Chengkun Hong, Yuhang Zhang, Hao Huang

Abstract readCase Reports
In one paragraph

Article in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Liyuan FuFuzong Teaching Hospital, Fujian University of Traditional Chinese Medicine (900th Hospital), Fuzhou, China.
Taipeng ZengFuzong Teaching Hospital, Fujian University of Traditional Chinese Medicine (900th Hospital), Fuzhou, China.ORCID 0009-0005-6161-9098
Chengkun HongFuzong Teaching Hospital, Fujian University of Traditional Chinese Medicine (900th Hospital), Fuzhou, China.
Yuhang ZhangFuzong Teaching Hospital, Fujian University of Traditional Chinese Medicine (900th Hospital), Fuzhou, China.
Hao HuangCollege of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China.

Funding

Joint Funds for Science and Technology Innovation of Fujian Province 2025Y9716School Management Project of Fujian University of Chinese Traditional Medicine X2025004Youth Science and Technology Innovation Talent Cultivation Program of FJTCM XQC2024004
6 · The paper itself

Abstract

rationalePrimary pulmonary lymphoma (PPL) is an extremely rare malignant lung tumor that is frequently misdiagnosed as pneumonia or lung cancer due to its atypical radiological and clinical presentation. The rationale of this report is to elucidate the diagnostic value of combining computed tomography (CT) and 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in evaluating a rare presentation of PPL. PATIENT CONCERNS: A 44-year-old male was admitted after an incidental lung lesion was discovered during routine screening. He was completely asymptomatic, lacking respiratory or systemic "B symptoms." DIAGNOSES: A baseline chest CT identified a 3.9 × 3.5 cm soft-tissue mass in the right hilar region that compressed the right upper lobe bronchus, leading to secondary post-obstructive consolidation that lacked the characteristic air bronchogram sign. The CT also revealed an incidental 2.6 × 2.6 cm anterior mediastinal nodule. Subsequent whole-body 18F-FDG PET/CT demonstrated intense tracer uptake in the right hilar mass with a maximum standardized uptake value of 7.1 and mild-to-moderate uptake in an adjacent regional lymph node (maximum standardized uptake value of 3.2). The scan showed completely absent uptake in the anterior mediastinal nodule and the post-obstructive consolidation, arguing against metabolically active malignancy in those areas. Histopathological and immunohistochemical analysis from a bronchoscopic transbronchial lung biopsy confirmed primary pulmonary mucosa-associated lymphoid tissue lymphoma.

interventionsThe patient underwent localized radiotherapy targeting the right hilar mass and the FDG-avid regional hilar/posterior mediastinal lymph node. A total dose of 66 Gy was delivered in 18 fractions over the course of 3 weeks. OUTCOMES: At the 2-month post-discharge follow-up, a repeat chest CT revealed a marked reduction in the size of both the hilar lesion and the regional lymph nodes. The patient remained completely asymptomatic, and his laboratory parameters normalized. LESSONS: Differentiating PPL from central lung cancer and coexisting benign mediastinal abnormalities presents a significant clinical challenge, particularly when atypical radiological features mimic aggressive carcinomas. Whole-body 18F-FDG PET/CT serves as an invaluable, noninvasive modality for metabolic characterization, accurate loco-regional staging, and preventing clinical overstaging by effectively differentiating metabolically active lymphoma from concurrent benign lesions.

Indexed as

Lung NeoplasmsLymphoma, B-Cell, Marginal ZoneAdultDiagnosis, DifferentialFluorodeoxyglucose F18HumansMalePositron Emission Tomography Computed TomographyTomography, X-Ray ComputedFluorodeoxyglucose F18case reportcomputed tomography imagingmaximum standardized uptake valueprimary pulmonary lymphoma

Identifiers

PMID42826325
PMCPMC13633006

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.