Evidence map›Paper›PMID 42826204›Full record

ArticleScience advances2026

Re-evaluating molecular clock maximum age calibrations revives pre-Ediacaran divergence estimates for animals.

Orin M Lole Durbin, Eliel S C Anttila, Derek E G Briggs, Francis A Macdonald, Ross P Anderson

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Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Orin M Lole DurbinDepartment of Earth Sciences, University of Oxford, Oxford OX1 3AN, UK.ORCID 0000-0003-4748-1895
Eliel S C AnttilaDepartment of Earth and Planetary Sciences, ETH Zürich, Zürich 8092, Switzerland.ORCID 0000-0002-7563-2710
Derek E G BriggsDepartment of Earth and Planetary Sciences and Yale Peabody Museum, Yale University, New Haven, CT 06511, USA.ORCID 0000-0003-0649-6417
Francis A MacdonaldDepartment of Earth and Planetary Sciences, University of California-Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0001-8416-4894
Ross P AndersonMuseum of Natural History, University of Oxford, Oxford OX1 3PW, UK.ORCID 0000-0002-0558-7563

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Divergent models persist for the emergence of animals. Lipid biomarkers suggest animals originated before 635 million years ago (Ma), but their body fossil record extends to only 574 Ma. Molecular clocks might differentiate between these records, but we demonstrate how their accuracy and precision hinge on maximum age calibrations. We evaluate the Ediacaran Weng'an Biota (China) as a maximum calibration utilizing microfossils from the Kheseen Biota (Mongolia). These two biotas have similar preservation and microfossil assemblages, containing no definitive animals. The Kheseen Biota, deposited at a time (∼550-526 Ma) when animals were undoubtedly present, questions the validity of the Weng'an calibration. We discuss the uncertainty in maximum calibration strategies and propose multiple pre-Ediacaran deposits with favorable taphonomy, preserving both non-animal body fossils and biomarkers, as currently the most reliable calibrations. Our analyses support a late Tonian to mid-Cryogenian (∼800-700 Ma) origin for Metazoa.

Indexed as

Biological EvolutionEvolution, MolecularFossilsAnimalsCalibrationChina

Identifiers

PMID42826204
PMCPMC13632735

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.