Evidence map›Paper›PMID 42826193›Full record

ArticleScience advances2026

Transposon end recognition and pairing by I-F3 CRISPR-associated transposase.

Vinh H Truong, Darcie J Miller, Shirin Fatma, Yuewen Sheng, Chinmai Pindi, Mohd Ahsan, Giulia Palermo, Elizabeth H Kellogg

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Vinh H TruongDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-6154-1228
Darcie J MillerDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Shirin FatmaDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-4504-4272
Yuewen ShengDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0003-3067-9520
Chinmai PindiDepartment of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-7873-013X
Mohd AhsanDepartment of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-0583-4413
Giulia PalermoDepartment of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA, USA.
Elizabeth H KelloggDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-9664-3179

Funding

Structural Basis of Programmable DNA-Insertion via Cryo-EM Studies of CRISPR-Associated TnsCR01GM144566 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Elizabeth Kellogg · 2022 to 2026
$2.0M
Investigating the metal-dependent function, allostery and inhibition of CRISPR-Cas9R01GM141329 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI PALERMO, GIULIA · 2021 to 2025
$1.7M
Mechanistic Studies of CRISPR-Cas9 Genome Editing Using Molecular Simulations and AI-Driven ApproachesR35GM164142 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI Giulia Palermo · 2026 to 2026
$421k
Structural and evolutionary basis for insertion unidirectionality in RNA-guided DNA transposition systemsF31GM151863 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL GRADUATE SCHOOL OF BIOMEDICAL SCIENCES, LLC · PI Vinh H Truong · 2023 to 2026
$147k
NIGMS NIH HHS F31 GM151863NIGMS NIH HHS R01 GM141329NIGMS NIH HHS R01 GM144566NIGMS NIH HHS R35 GM164142
6 · The paper itself

Abstract

To develop gene therapy tools based on CRISPR-associated transposons (CASTs), it is essential to define how transposon ends are recognized and paired during transposition. Transposon

Indexed as

CRISPR-Cas SystemsDNA Transposable ElementsTransposasesCryoelectron MicroscopyModels, MolecularMolecular Dynamics SimulationProtein BindingDNA Transposable ElementsTransposases

Identifiers

PMID42826193
PMCPMC13632737

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.