In one paragraphArticle in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
39 authors.
Andrea PasquadibisceglieTelethon Institute of Genetics and Medicine (TIGEM), 80078 Pozzuoli, Italy.
Paola ArenaTelethon Institute of Genetics and Medicine (TIGEM), 80078 Pozzuoli, Italy.
Matteo AudanoDepartment of Pharmacology and Biomolecular Sciences, University of Milan, 20133 Milan, Italy.
Nico MitroDepartment of Pharmacology and Biomolecular Sciences, University of Milan, 20133 Milan, Italy.ORCID 0000-0002-5000-3619 Tsuyoshi MoritaOral and Maxillofacial Anatomy, Tokushima University Graduate School, Tokushima 770-8504, Japan.ORCID 0000-0002-5023-4484 Otto BabaOral and Maxillofacial Anatomy, Tokushima University Graduate School, Tokushima 770-8504, Japan.ORCID 0009-0005-6444-2945 Sonam GurungGreat Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.ORCID 0000-0003-3271-5273 Dany P PerocheauGreat Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.ORCID 0000-0001-5450-8801 Davide SelvestrelInternational Centre for Genetic Engineering and Biotechnology (ICGEB), 34149 Trieste, Italy.ORCID 0009-0007-8959-6670 Giovanni SorrentinoInternational Centre for Genetic Engineering and Biotechnology (ICGEB), 34149 Trieste, Italy.
Fabienne RajasUniversité Claude Bernard Lyon 1, INSERM UMR-S1213, Lyon 69008, France.
Giuseppe RonzittiUniversité Paris-Saclay, Université Évry, Inserm, Genethon, Integrare research unit UMR_S951, Evry 91000, France.ORCID 0000-0002-9184-0210 Andrés F MuroInternational Centre for Genetic Engineering and Biotechnology (ICGEB), 34149 Trieste, Italy.ORCID 0000-0002-9628-0494 Ayelet ErezDepartment of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.ORCID 0000-0002-9696-0393 Karen Louise ThomsenDepartment of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus N DK-8200, Denmark.ORCID 0000-0002-8118-4643 Pankaj K SinghDepartment of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0001-9626-5182 Charles John ArendsDepartment of Pediatrics, University of Connecticut School of Medicine, Farmington, CT 06030, USA.
Maria Rita BraghiniResearch Unit of Complex Traits, Bambino Gesù Children's Hospital, IRCCS, 00146 Rome, Italy.
Samira SafarikiaBambino Gesù Children's Hospital, IRCCS, 00146 Rome, Italy.
Joseph C SchindlerInstitute for Transformative Molecular Medicine and Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.ORCID 0000-0001-7034-9556 Julien BaruteauGreat Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.ORCID 0000-0003-0582-540X Young Mok LeeDepartment of Pediatrics, University of Connecticut School of Medicine, Farmington, CT 06030, USA.ORCID 0000-0002-6304-8883 Anna AlisiResearch Unit of Complex Traits, Bambino Gesù Children's Hospital, IRCCS, 00146 Rome, Italy.ORCID 0000-0001-7241-6329 Jonathan S StamlerInstitute for Transformative Molecular Medicine and Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.ORCID 0000-0002-6866-1572 Matthew S GentryDepartment of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0001-5253-9049 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Nuclear glycogen storage has been known for nearly 100 years. However, its role in diseases remains unclear. Here, we found nuclear glycogen storage in livers of mice and humans with argininosuccinic aciduria (ASA), an inborn error of metabolism. Nuclear glycogenolysis sustains histone acetylation and liver homeostasis. We show that hepatic nuclear glycogenolysis is regulated by nitric oxide (NO)-dependent control of the nuclear abundance of liver glycogen phosphorylase (PYGL), an enzyme involved in glycogen breakdown that translocates from the cytosol to the nucleus. In vivo, NO supplementation restored the nuclear content of PYGL by promoting its
Indexed as
Cell NucleusGlycogenolysisGlycogen PhosphorylaseLiver DiseasesAnimalsGlycogenHumansLiverMiceNitric OxideGlycogenGlycogen PhosphorylaseNitric Oxide
Identifiers
PMID42826186
PMCPMC13632743
What OpenQuestion holds
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