Evidence map›Paper›PMID 42826183›Full record

ArticleScience advances2026

Structural and kinetic mechanisms of state-dependent potassium channel inhibition.

Efthimios Kyriakis, Agnese Roscioni, Jodene Eldstrom, Daniel Sastre, Ying Dou, Alice Taddei, Steven Molinarolo, Michael Tian, Luca Maragliano, Filip Van Petegem and 1 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Efthimios KyriakisThe Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver V6T 1Z3, Canada.ORCID 0000-0002-9183-8970
Agnese RoscioniDepartment of Life and Environmental Sciences, Polytechnic University of Marche, Via Brecce Bianche, Ancona 60131, Italy.ORCID 0009-0005-2681-8243
Jodene EldstromThe Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver V6T 1Z3, Canada.ORCID 0000-0002-7684-175X
Daniel SastreThe Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver V6T 1Z3, Canada.ORCID 0000-0001-9471-9398
Ying DouThe Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver V6T 1Z3, Canada.
Alice TaddeiDepartment of Life and Environmental Sciences, Polytechnic University of Marche, Via Brecce Bianche, Ancona 60131, Italy.ORCID 0009-0004-3992-1736
Steven MolinaroloThe Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver V6T 1Z3, Canada.ORCID 0000-0002-6077-1291
Michael TianThe Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver V6T 1Z3, Canada.ORCID 0009-0009-7688-2170
Luca MaraglianoDepartment of Life and Environmental Sciences, Polytechnic University of Marche, Via Brecce Bianche, Ancona 60131, Italy.ORCID 0000-0002-5705-6967
Filip Van PetegemThe Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver V6T 1Z3, Canada.ORCID 0000-0003-2728-8537
David FedidaThe Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver V6T 1Z3, Canada.ORCID 0000-0001-6797-5185

Funding

GENE THERAPY FOR HEPATITIS C INFECTION--CHRONIC INFECTIOUS DISEASE MODELZ01CL002077 · CLC · CLINICAL CENTER · PI SHIH, J W · 1996 to 1998
–
Intramural NIH HHS Z01 CL002077
6 · The paper itself

Abstract

The KCNQ1 (Kv7.1) potassium ion (K

Indexed as

KCNQ1 Potassium ChannelPotassium Channel BlockersBinding SitesCryoelectron MicroscopyHumansIon Channel GatingKineticsMolecular Dynamics SimulationProtein BindingProtein ConformationKCNQ1 Potassium ChannelPotassium Channel Blockers

Identifiers

PMID42826183
PMCPMC13632742

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.