Evidence map›Paper›PMID 42825988›Full record

ArticleFolia microbiologica2026

Linsitinib: a tyrosine kinase inhibitor with dual host-parasite targeting potential against leishmaniasis.

Lalit Nharwal, Mirza Adil Beg, Rahul Singh, Vivek Dhar Dwivedi, Farhan Jalees Ahmad, Angamuthu Selvapandiyan, Garima Chouhan

Abstract read
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In one paragraph

Article in Folia microbiologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lalit NharwalDrug Discovery and Immunology Laboratory, Department of Biotechnology, Sharda School of Bioscience and Technology, Sharda University, Greater Noida, Uttar Pradesh, 201310, India.ORCID http://orcid.org/0009-0009-0543-7053
Mirza Adil BegDepartment of Molecular Medicine, School of Interdisciplinary Sciences and Technology, Jamia Hamadard, New Delhi, 110062, India.ORCID http://orcid.org/0000-0002-0362-8691
Rahul SinghDrug Discovery and Immunology Laboratory, Department of Biotechnology, Sharda School of Bioscience and Technology, Sharda University, Greater Noida, Uttar Pradesh, 201310, India.ORCID http://orcid.org/0009-0000-5118-7424
Vivek Dhar DwivediBioinformatics Research Division, Quanta Calculus, Greater Noida, Uttar Pradesh, 201310, India.ORCID http://orcid.org/0000-0003-0767-1328
Farhan Jalees AhmadDepartment of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India.ORCID http://orcid.org/0000-0002-0740-8573
Angamuthu SelvapandiyanDepartment of Molecular Medicine, School of Interdisciplinary Sciences and Technology, Jamia Hamadard, New Delhi, 110062, India.ORCID http://orcid.org/0000-0002-2194-1534
Garima ChouhanDrug Discovery and Immunology Laboratory, Department of Biotechnology, Sharda School of Bioscience and Technology, Sharda University, Greater Noida, Uttar Pradesh, 201310, India. garimachouhan68@gmail.com.ORCID http://orcid.org/0000-0002-8890-8691

Funding

Indian Council of Medical Research 6/9-7(241)/2020-ECD-II
6 · The paper itself

Abstract

Leishmaniasis is a vector-borne parasitic disease caused by Leishmania spp., that contributes substantially to global morbidity. Considering the toxicity, drug resistance and limited efficacy of current therapies, drug repositioning represents an efficient approach for identifying novel antileishmanial agents from existing pool of drugs. In this context, we evaluated antileishmanial potential of Linsitinib, a known tyrosine kinase inhibitor and an anticancer molecule in advance stages of development. Linsitinib demonstrated potent anti-proliferative activity with IC

Identifiers

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.