Evidence map›Paper›PMID 42825856›Full record

ReviewMolecular biomedicine2026

Bile acid signaling in health and disease.

Zhezhe Fan, Mengyi He, Taiping Liang, Bili Zhang, Na Zhao, Pan Li

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhezhe Fan *Department of Anesthesiology, Changzheng Hospital, Naval Medical University, Shanghai, 200003, China.
Mengyi He *Department of Anesthesiology, First Medical Centre, Chinese People's Liberation Army (PLA) General Hospital, Beijing, 100853, China.
Taiping Liang *Department of Vascular Surgery, Changhai Hospital, Naval Medical University, 168 Changhai Rd, Shanghai, 200433, China.
Bili ZhangDepartment of Cardiology, Changhai Hospital, Naval Medical University, 168 Changhai Rd, Shanghai, 200433, China. smmuzhangbili@163.com.
Na ZhaoSchool of Anesthesiology, Naval Medical University, 800 Xiangyin Road, Shanghai, 200433, China. zhaona2023@163.com.
Pan LiDepartment of Cardiology, Changhai Hospital, Naval Medical University, 168 Changhai Rd, Shanghai, 200433, China. lipansmmu@163.com.

Funding

National Natural Science Foundation of China 82170275
6 · The paper itself

Abstract

Bile acids (BAs), cholesterol-derived amphipathic metabolites which are traditionally regarded as digestive surfactants, are now recognized as pleiotropic signaling molecules that act through ligand-, receptor-, and tissue-specific mechanisms to maintain systemic homeostasis. They exert biological functions via nuclear receptors (FXR, PXR, VDR, CAR) and membrane receptors (TGR5, S1PR2, MRGPRX4). These receptors activate transcriptional and membrane-initiated programs, including FXR-SHP/FGF19 feedback, TGR5-cAMP-PKA signaling, S1PR2-ERK/AKT/RhoA pathways, MRGPRX4-dependent Ca

Indexed as

Bile Acids and SaltsSignal TransductionAnimalsHumansReceptors, Cytoplasmic and NuclearBile Acids and SaltsReceptors, Cytoplasmic and NuclearBile acid pool compositionBile acidsFXRHydrophilicityTGR5

Identifiers

PMID42825856

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.