Evidence map›Paper›PMID 42825834›Full record

ArticleCellular and molecular neurobiology2026

β-Hydroxybutyrate Maintains Energetically Demanding Neural Functions During Exogenous Glucose Deprivation.

Rachel L Ricks, Dallin S Nevers, Tyler Poulos, T Luke Shafer, Clayton Dunford, Jason M Hansen, Paul R Reynolds, Benjamin T Bikman, R Ryley Parrish

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rachel L RicksDepartment of Cell Biology and Physiology, Brigham Young University, Provo, UT, USA.ORCID http://orcid.org/0009-0005-4508-7490
Dallin S NeversNeuroscience Center, Brigham Young University, Provo, UT, USA.ORCID http://orcid.org/0009-0007-3335-7136
Tyler PoulosDepartment of Cell Biology and Physiology, Brigham Young University, Provo, UT, USA.ORCID http://orcid.org/0009-0004-1363-2629
T Luke ShaferNeuroscience Center, Brigham Young University, Provo, UT, USA.ORCID http://orcid.org/0009-0005-4632-7804
Clayton DunfordDepartment of Cell Biology and Physiology, Brigham Young University, Provo, UT, USA.ORCID http://orcid.org/0009-0000-7970-8623
Jason M HansenDepartment of Cell Biology and Physiology, Brigham Young University, Provo, UT, USA.ORCID http://orcid.org/0000-0001-9781-6433
Paul R ReynoldsDepartment of Cell Biology and Physiology, Brigham Young University, Provo, UT, USA.ORCID http://orcid.org/0000-0002-0931-3025
Benjamin T BikmanDepartment of Cell Biology and Physiology, Brigham Young University, Provo, UT, USA.ORCID http://orcid.org/0000-0003-3680-6906
R Ryley ParrishDepartment of Cell Biology and Physiology, Brigham Young University, Provo, UT, USA. ryley_parrish@byu.edu.ORCID http://orcid.org/0000-0001-6798-6140

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ketone bodies are a major source of cerebral energy during fasting and the ketogenic diet, but whether they can sustain brain tissue metabolism when glucose is absent remains uncertain. This question is difficult to resolve in vivo because circulating glucose is maintained, even during starvation, through endogenous production. We therefore used an ex vivo brain preparation to examine the metabolic capacity of tissue following incubation with β-hydroxybutyrate (BHB) as the only exogenous fuel, isolating brain tissue from its primary endogenous glucose sources. Mitochondrial respiration was monitored following 4-hour incubation in glucose-free, BHB-rich artificial cerebrospinal fluid, and tissue resilience was tested by inducing spreading depolarization, a severe energetic challenge that requires rapid restoration of ionic and metabolic homeostasis. Following acute reliance on exogenous BHB, in addition to endogenous energy reserves, mitochondrial electron transfer system function persisted, with lower O

Indexed as

3-Hydroxybutyric AcidBrainEnergy MetabolismGlucoseNeuronsAnimalsMitochondriaRats, Sprague-Dawley3-Hydroxybutyric AcidGlucoseBrain metabolismEnergeticsKetonesSpreading depolarizationSpreading depression

Identifiers

PMID42825834
PMCPMC13633234

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.