Evidence map›Paper›PMID 42825819›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2026

First-in-human dosimetry and biodistribution of [

Kadir Gultekin, Jennifer L Bartels, Carlos E Cardenas, Yogesh Kumar, Grayson R Gimblet, Chloe L Jones, Christina Bankston, Charlotte D Jeffers, Sharon L White, Suzanne E Lapi and 2 more

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03807973 (Tracking Peripheral Immune Cell Infiltration of the Brain in Central Inflammatory Disorders Using [Zr-89]Oxinate-4-labeled Leukocytes.), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03807973 phase1suspendednot on this map

Tracking Peripheral Immune Cell Infiltration of the Brain in Central Inflammatory Disorders Using [Zr-89]Oxinate-4-labeled Leukocytes.

TypeinterventionalSponsorUniversity of Alabama at BirminghamRan2021 to 2028Enrolled120ConditionsFibromyalgia, Chronic Fatigue Syndrome, Multiple Sclerosis, HealthyArms[Zr-89]Oxine-labeled leukocytes PET/MRI
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kadir GultekinDepartment of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.ORCID http://orcid.org/0000-0002-9736-6302
Jennifer L BartelsDepartment of Radiology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.ORCID http://orcid.org/0000-0002-0137-2397
Carlos E CardenasDepartment of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID http://orcid.org/0000-0003-1414-3849
Yogesh KumarDepartment of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID http://orcid.org/0000-0002-2800-0235
Grayson R GimbletDepartment of Radiology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.ORCID http://orcid.org/0000-0002-1312-9714
Chloe L JonesDepartment of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID http://orcid.org/0000-0002-7288-8235
Christina BankstonDepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID http://orcid.org/0000-0002-6127-6700
Charlotte D JeffersDepartment of Radiology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Sharon L WhiteDepartment of Radiology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Suzanne E LapiDepartment of Radiology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.ORCID http://orcid.org/0000-0003-0090-0191
Jarred W YoungerDepartment of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID http://orcid.org/0000-0003-3616-9919
Jonathan E McConathyDepartment of Radiology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA. mcconatj@mcmaster.ca.ORCID http://orcid.org/0000-0003-4681-2322

Funding

Myalgic Encephalomyelitis Research UK (MERUK) Myalgic Encephalomyelitis Research UK (MERUK)University of Alabama Health Services Foundation HSFGEF7263
6 · The paper itself

Abstract

purposeCell tracking with zirconium-89 PET has the potential for widespread clinical and research applications, including imaging infection and inflammation and tracking cell-based therapies. This prospective first-in-human clinical trial assessed the dosimetry and safety profile of [

methodsFour healthy adult female participants (ages 37-53) received 10.9 ± 2.9 MBq of [

resultsAdministration was well-tolerated among all participants. The highest mean absorbed-dose coefficients (mGy/MBq) with standard deviation were observed in the spleen (3.52 ± 1.38), liver (2.1 ± 0.45), adrenals (1.62 ± 0.24), uterus (1.48 ± 0.98), and kidneys (1.36 ± 0.12). The mean effective-dose coefficient was 0.92 ± 0.06 mSv/MBq, numerically lower than the predicted value of 1.14 mSv/MBq based on the distribution of [

conclusionThis study demonstrates the safety and favorable dosimetry of [

trial registrationClinicalTrials.gov NCT03807973. Registered January 16, 2019.

Indexed as

Cell trackingDosimetryLeukocytesOxinePETZirconium-89

Identifiers

PMID42825819

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.